In the research area “Medical Sensors” we focus on the implementation of various sensor technologies into applications in the clinical environment. We drive the development of new sensing methods from the fundamental idea to experimental models and prototypes for clinical testing. The portfolio of the research area includes:

• sensors for in vivo monitorig
• sensors for ex vivo monitoring
• in vitro diagnostics
• bioimpedance systems
• sensor evaluation

The miniaturization of sensor geometries and the integration of sensor elements in microfluidic structures enables the monitoring of key analytes in various tissues in vivo. Medical accuracy is required besides minimal invasiveness, ease of use and consumer friendly handling.
Online glucose monitoring for improved diabetes management is still a demanding task for in vivo sensing. Our novel single port approach combines continuous glucose measurement and simultaneous insulin infusion by integration of the glucose sensing element into the insulin infusion catheter.

The combination of our sensor systems with different sampling techniques, such as Open Flow Microperfusion and Microdialysis, allow for the development of various applications for special clinical needs.

Due to these minimal invasive catheters, the body response is reduced and the sensing surfaces are protected against biofouling.

Additionally smart calibration procedures and measurement of supporting parameters offer opportunities for improved accuracy of the measuring system.

We develop sensors for in-vitro diagnostics, especially for the „Point of Care“ market. In this segment quick measuring procedures and direct measurement in native samples are essential.

Currently we develop a measuring system, which allows for the identification of a wound infection by measuring a specific biomarker even before first symptoms of an infection occur.

We support the development of medical measuring systems including sensor-design, calibration procedures and work-flow analysis. Additionally we evaluate sensor performance in pre-clinical and clinical studies and test the system-usability in a clinical setting.

Many properties of different tissues can be measured directly or indirectly by impedance sprectroscopy.

Currently a bioimpedance method is under development, which is suitable for quanitification of the permeability of the skin for topically applied drugs.