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MitarbeiterInnen

Telefon: +43 316 876-2121
Fax: +43 316 8769-4000
frank.sinner@joanneum.at

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8010 Graz
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Hauptaufgaben Stellvertretender Institutsleiter Forschungsgruppenleiter Akquisition und Mitarbeiterführung Wissenschaftlicher Koordinator des Verbundprojektes Nano-Health Werdegang Analytischer Chemiker mit Schwerpunkt Bioanalytik und Polymerchemie Diplomstudium an der TU Graz Auslandsaufenthalte an der Université de Perpignan Erlangung der Maîtrise de Chimie et Biologie Végétale Appliquées Viele Praktika im europäischen wie außereuropäischen Ausland Diplomarbeit (später in seiner Dissertation) Thema: "Neue monolithische und geträgerte stationäre Phasen" Besitz dreier Patente Fundierte Erfahrungen im Bereich Qualitätsmanagement Seit 2001: Leiter des Schwerpunktes Bioanalytik Seit 2006: Geschäftsführer der BioNanoNet Forschungsgesellschaft mbH (www.bionanonet.at) Seit 2007: Stellvertretender Institutsleiter für den Bereich Bioanalytik Seit 2009: Stellvertretender Institutsleiter für die Bereiche präklinische und klinische Forschung und Bioanalytik Interessensgebiete Interdisziplinäre Ansätze in der medizinischen Forschung Networking Projekte Verbundprojekt Nano-Health – Nanostructured Materials for Drug Targeting, Release and Imaging Publikationen A New Class of Continuous Rods as Stationary Phases Prepared by Ring-Opening Metathesis Polymerization: A Straight Forward Route to Functionalized Monoliths A Robust and Easy Method for Simultaneous Quantitation of Glucose and [6,6-d2] Glucose in Human Plasma using GC-MS Chiral Polymer Supports Prepared via Ring-Opening Metathesis Graft-Polymerization. Scopes and Limitations DAS INTERSTITIUM: EINE ANALYTISCHE HERAUSFORDERUNG Dipyridyl Amide-Functionalized Polymers by Ring-Opening-Metathesis Polymerization (ROMP) for the Selective Extraction of Mercury and Palladium Duration of action, pharmacodynamic profile and between-subject variability of insulin detemir in subjects with Type 1 diabetes Evaluation of norbornene-ß-cyclodextrin-based monomers and polymers as chiral selectors by means of non-aqueous capillary electrophoresis Functional Monolithic Capillary Columns Prepared by Ring-Opening Metathesis Polymerization Influence of different sample preparation techniques on the simultaneous quantification of different insulins in serum using cap-HPLC/MS2 Ion-Exchange Monolithic Capillary Columns Prepared by Ring-Opening Metathesis Polymerization Ionization efficiency of phospholipid classes in negative electrospray ionization mass spectrometry LC/MS/MS Method for Quantitative Determination of Long-Chain Fatty Acyl-CoAs Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access. Monolithic capillary columns prepared by ring-opening metathesis polymerisation Monolithic Stationary Phases Prepared by Ring-Opening Metathesis Polymerisation for cap-HPLC Monolithic Stationary Phases Prepared by Ring-Opening Metathesis Polymerisation: Influence of Different Polymerisation Parameters on Separation Performance Mögliche Hepatoselektivität von Insulin Detemir im Vergleich zu NPH Insulin in Patienten mit Typ-1-Diabetes Particle-Loaded Monoliths for Enantioseparation by Capillary Electrochromatography Protracted pharmacodynamic profile and high between-subject predictability with insulin detemir in subjects with type 1 diabetes Ring-Opening Metathesis Polymerization for the Preparation of Surface-Grafted Polymer Supports Ringöffnende Metathesepolymerisation: Zugang zu einer neuen Klasse funktionalisierter, monolithischer stationärer Phasen für die Flüssigkeitschromatographie Strategies for Quantification of Insulin and Insulin Analogues by LC MS/MS Tailor-Made Polymer Supports via Metathesis Polymerization: Concept and Application The interstitium: an analytical challenge
Projekte Bestimmung von Stoffwechselmetaboliten in biologischen Geweben Bioanalytik zu Nanotransderm Dermales Zytokinsampling (Dermalyt) Spezialanalytik für Liposam: DERMALES SAMPLING FÜR PK-PD VON LIPOPHILEN TOPISCHEN ARZNEIMITTELN Strukturaufklärung und Identifikation von Verunreinigungen pharmakologischen Wirkstoffen
Publikationen A double-blind, randomized, dose-response study investigating the pharmacodynamic and pharmacokinetic properties of the long-acting insulin analog detemir. A New Class of Continuous Rods as Stationary Phases Prepared by Ring-Opening Metathesis Polymerization: A Straight Forward Route to Functionalized Monoliths A new strategy for the sensitive and simultaneous analysis of human insulin and insulin analogues using LC/MS² in combination with a tailored sample clean-up procedure A novel minimally-invasive approach for investigations into skin barrier function and percutaneous drug penetration A Robust and Easy Method for Simultaneous Quantitation of Glucose and [6,6-d2] Glucose in Human Plasma using GC-MS A validated analytical method for the dermination of L-Cystine, N-Acetyl-L-Cysteine, L-Cysteine and rearrangement products in amino acid solutions by LC/MS/MS Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats. Activities and funding programmes for nanomedicine in Austria Acyl CoA-Profiling in Biological Tissues using Online SPE-LC-FTMS (Orbitrap) BioNanoNet Buccal permeability studies of nanostructured materials and the structural concept of the European Center for Nanotoxicology Chiral beta-cyclodextrin-based polymer supports prepared via ring-opening metathesis graft-polymerization. Chiral Polymer Supports Prepared via Ring-Opening Metathesis Graft-Polymerization. Scopes and Limitations Comparison of fenoprofen and deuterated ketoprofen as internal standards for ketoprofen analysis in microdialysis and open-flow microperfusion samples Comparison of open-flow microperfusion and microdialysis methodologies when sampling topically applied fentanyl and benzoic acid in human dermis ex vivo. DAS INTERSTITIUM: EINE ANALYTISCHE HERAUSFORDERUNG Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling DermAxess: Access to continuous in-vivo sampling in skin for realistic probes Development of Capillary-Scale Monolithic Supports for On-Line Sample Pre-treatment in Nanomedical Research Dipyridyl Amide-Functionalized Polymers by Ring-Opening-Metathesis Polymerization (ROMP) for the Selective Extraction of Mercury and Palladium Duration of action, pharmacodynamic profile and between-subject variability of insulin detemir in subjects with Type 1 diabetes Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase. Enantioseparation of glycyl-dipeptides by CEC using particle-loaded monoliths prepared by ring-opening metathesis polymerization (ROMP). Enantioseparation of glycyl-dipeptides by CEC using particle-loaded monoliths prepared by ring-opening metathesis polymerization (ROMP). Enantioseparation of glycyl-dipeptides by CEC using particle-loaded monoliths prepared by ring-opening metathesis polymerization (ROMP). Euronanotox, The European Center for Nanotoxicology - An Austrian hub for Nanotoxicology European Center for Nanotoxicology: the Austrian Hub for Nanosafety European Center for Nanotoxicology:: the Austrian Hub for Nanosafety Evaluation of different techniques for subcutaneous glucose monitoring in type 1 diabetic patients during “real-life” glucose excursions Evaluation of ion-pairing reagents for phospholipid class separation by normal phase HPLC using negative electrospray ionization mass spectrometry detection Evaluation of norbornene- beta-cyclodextrin-based monomers and oligomers as chiral selectors by means of nonaqueous capillary electrophoresis. Evaluation of norbornene-ß-cyclodextrin-based monomers and polymers as chiral selectors by means of non-aqueous capillary electrophoresis Evaluation of ring-opening metathesis polymerization (ROMP)-derived monolithic capillary high performance liquid chromatography columns. Evaluierung von Techniken zum subkutanen Glukosemonitoring bei Typ-1-Diabetikern Functional Monolithic Capillary Columns Prepared by Ring-Opening Metathesis Polymerizatio Functional Monolithic Capillary Columns Prepared by Ring-Opening Metathesis Polymerization Functional, ROMP-Based Materials for Life Sciences Functionalization of ROMP-derived monolithic capillary columns and their chromatographic properties Functionalized monolithic materials: syntheses, structures and use in life sciences, tissue engineering and heterogeneous catalysis Handhabung und Sicherheit von Nanopulvern Headspace-SPME-GC/MS as a simple cleanup tool for sensitive 2,6-diisopropylphenol analysis from lipid emulsions and adaptable to other matrices. Highly Efficient, Multifunctional Nanoparticle for Diagnostics Induction of autophagy by spermidine promotes longevity. Influence of different sample preparation techniques on the simultaneous quantification of different insulins in serum using cap-HPLC/MS2 Insulin glulisine, insulin lispro and regular human insulin show comparable end-organ metabolic effects: an exploratory study. Insulin glulisine, insulin lispro and regular human insulin show comparable end-organ metabolic effects: an exploratory study. Ion-Exchange Monolithic Capillary Columns Prepared by Ring-Opening Metathesis Polymerization Ion-exchange monolithic stationary phases prepared by ring-opening metathesis polymerization Ionization efficiency of phospholipid classes in negative electrospray ionization mass spectrometry Kirk, Spock und die Medizintechnik Episode 2 LC/MS/MS Method for Quantitative Determination of Long-Chain Fatty Acyl-CoAs LC/MS/MS method for quantitative determination of long-chain fatty acyl-CoAs. Lipidomics Based Design of Novel Antimicrobial Peptides Against Methicillin-Resistant Staphylococcus Aureus Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access. Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access. Medical Sensor Solutions - a styrian Innovation Alliance Miniaturised Monolithic Pre-columns prepared by ROMP for On-line Clean-up of Crude Nanoparticle-containing Samples Monolithic capillary columns prepared by ring-opening metathesis polymerisation Monolithic Capillary Columns Prepared by Ring-Opening Metathesis Polymerization and their Application in Medical Research Monolithic Stationary Phases Prepared by Ring-Opening Metathesis Polymerisation for cap-HPLC Monolithic Stationary Phases Prepared by Ring-Opening Metathesis Polymerisation: Influence of Different Polymerisation Parameters on Separation Performance Mögliche Hepatoselektivität von Insulin Detemir im Vergleich zu NPH Insulin in Patienten mit Typ-1-Diabetes Nano Health: aims and results of a joint research project of the Austrian NANO-Initiative Nanomedicine – Opportunities und Drawbacks Nanomedizin: Chancen und Risiken Nanoscale Material: A new challenge for toxicology Nanotechnologie in der Medizin mit besonderem Focus auf mögliche gesundheitliche Auswirkungen Nanotechnologie: Chancen und Risiken Neue Trennphasen für duie klinische Forschung New Methods for Bioprocess Modeling and Monitoring: A Mulitdisciplinary Approach New nanoparticle-based approaches for in-vivo diagnostics and therapy New strategy for insulin andinsulin analogs quantification – MRM detection for insulin B chain Norbornene-based Monolithic Pre-Columns for LC/MS Analysis in Nanomedical Research Novel catheters for in vivo research and pharmeceutical trials providing direct access to extracellular space of target tissues Online SPE-LC/FTMS (Orbitrap) Technique for Metabolite Profiling (Acyl CoAS) Optimization of Norbornene-Based Monolithic Pre-Columns for their use in Nanomedical Research Particle-Loaded Monoliths for Enantioseparation by Capillary Electrochromatography Poly(cyclooctene)-based monolithic columns for capillary high performance liquid chromatography prepared via ring-opening metathesis polymerization. Poly(Cyclooctene)-Based Monolithic Columns for µ-HPLC Prepared via Ring-Opening Metathesis Polymerization (ROMP) Potenzielle Gefahren für die menschliche Gesundheit von nanostrukturierten Materialien Profiling of Acyl CoAs in Biological Tissues using Online SPE-LC-FTMS (Orbitrap) Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment. Proportional dose-response relationship and lower within-patient variability of insulin detemir and NPH insulin in subjects with type 1 diabetes mellitus. Proportional dose-response relationship and lower within-patient variability of insulin detemir and NPH insulin in subjects with type 1 diabetes mellitus. Protracted pharmacodynamic profile and high between-subject predictability with insulin detemir in subjects with type 1 diabetes Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion. Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion. Ring-Opening Metathesis Polymerisation-derived Capillary Monoliths: Versatile Analytical Tools for Modern Biomedical Research Ring-Opening Metathesis Polymerisation-derived Capillary Monoltihs: Versatile Analytical Tools for Biomedical Research Ring-Opening Metathesis Polymerisation-derived Capillary Monoltihs: Versatile Analytical Tools for Modern Biomedical Research Ring-Opening Metathesis Polymerization for the Preparation of Functionalized Monolithic Stationary Phases used in Chromatography Ring-opening metathesis polymerization for the preparation of norbornene-based weak cation-exchange monolithic capillary columns. Ring-opening metathesis polymerization for the preparation of norbornene-based weak cation-exchange monolithic capillary columns. Ring-Opening Metathesis Polymerization for the Preparation of Surface-Grafted Polymer Supports Ring-opening metathesis polymerization-derived capillary monoliths: versatile analytical tools for modern biomedical research Ring-opening metathesis polymerization-derived capillary monoliths: versatile analytical tools for modern biomedical research Ring-opening metathesis polymerization-derived monolithic capillary columns for high-performance liquid chromatography. Downscaling and application in medical research Ring-opening metathesis polymerization-derived monolithic capillary columns for high-performance liquid chromatography: downscaling and application in medical research. Ring-opening metathesis polymerization: Access to a new class of functionalized , monolithic stationary phases for liquid chromatography Ringöffnende Metathesepolymerisation: Zugang zu einer neuen Klasse funktionalisierter, monolithischer stationärer Phasen für die Flüssigkeitschromatographie ROMP-based monolithic capillary columns as ESI-Interface for fast and sensitive LC-MS analysis Romp-based monolithic capillary columns for ion-exchange liquid chromatography ROMP-derived monolithic capillary pre-columns for on-line SPE of nanoparticles Searching for the optimal methodology for dermal in vivo sampling Searching for the optimal methodology for dermal in vivo sampling. Senstive insulin analysis in interstitial fluid: Influence of mobile phase additives on insulin B chain loading efficiency in CAP-HPLC/MS Spermidine promotes mating and fertilization efficiency in model organisms. Strategies for Quantification of Insulin and Insulin Analogues by LC MS/MS Strategies for sensitive peptide detection in brain homogenate using LC/MS for the purpose of blood-brain-delivery testing Subcutaneous glucose monitoring in patients with severe sepsis Tailor-Made Polymer Supports via Metathesis Polymerization: Concept and Application The European Center of Nanotoxicology - An Austrian Activity The interstitium: an analytical challenge The propeptide of yeast cathepsin D inhibits programmed necrosis. The Utility of ROMP for the Preparation of Functionalized Monoliths: Capillary Column Synthesis and their Separation Properties Ultrafiltration as a purification step in sample preparation for LC/MS² analysis of insulin in serum Validated comprehensive analytical method for quantification of coenzyme A activated compounds in biological tissues by online solid-phase extraction LC/MS/MS. Validated Comprehensive Analytical Method for Quantification of Coenzyme-A Activated Compounds in Biological Tissues by Triple Quadrupol LC/MS/MS Voltage-assisted capillary LC of peptides using monolithic capillary columns prepared by ring-opening metathesis polymerization. Voltage-assisted capillary LC of peptides using monolithic capillary columns prepared by ring-opening metathesis polymerization.

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