Main responsibilities

• Deputy head of institute for the field of preclinical and clinical research and the department of bioanalytics
• Acquisition and leadership
• Scientific coordinator of the joint research project Nano-Health

Career

• Analytical chemist specialising in bioanalysis and polymer chemistry
• Graduate of Graz University of Technology
• Research stays at the Universitè de Perpignan MaItrise de Chimie et Biologie Vegetale Alliquees
• Extensive practical training both within and ouside Europe
• Diploma thesis (and doctoral thesis) on: "New monolithic and supported stationary phases"
• Holder of three patents
• Sound experience in the field of quality management
• Bioanalysis Teaching
• since 2001: Head of the department of bioanalytics
• since 2006: Managing director of the BioNanoNet Forschungsgesellschaft mbH (www.bionanonet.at)
• since 2007: Deputy of the head of institute for the department bioanalytics
• since 2009: Deputy of the head of institute for preclinical and clinical research and the department bioanalytics

Fields of interests

• Interdisciplinarity in medical research
• Networking

Projects

• Joint research project Nano-Health – Nanostructured Materials for Drug Targeting, Release and Imaging

Publications

A New Class of Continuous Rods as Stationary Phases Prepared by Ring-Opening Metathesis Polymerization: A Straight Forward Route to Functionalized Monoliths

A Robust and Easy Method for Simultaneous Quantitation of Glucose and [6,6-d2] Glucose in Human Plasma using GC-MS

Chiral Polymer Supports Prepared via Ring-Opening Metathesis Graft-Polymerization. Scopes and Limitations

DAS INTERSTITIUM: EINE ANALYTISCHE HERAUSFORDERUNG

Dipyridyl Amide-Functionalized Polymers by Ring-Opening-Metathesis Polymerization (ROMP) for the Selective Extraction of Mercury and Palladium

Duration of action, pharmacodynamic profile and between-subject variability of insulin detemir in subjects with Type 1 diabetes

Evaluation of norbornene-ß-cyclodextrin-based monomers and polymers as chiral selectors by means of non-aqueous capillary electrophoresis

Functional Monolithic Capillary Columns Prepared by Ring-Opening Metathesis Polymerization

Influence of different sample preparation techniques on the simultaneous quantification of different insulins in serum using cap-HPLC/MS2

Ion-Exchange Monolithic Capillary Columns Prepared by Ring-Opening Metathesis Polymerization

Ionization efficiency of phospholipid classes in negative electrospray ionization mass spectrometry

LC/MS/MS Method for Quantitative Determination of Long-Chain Fatty Acyl-CoAs

Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access.

Monolithic capillary columns prepared by ring-opening metathesis polymerisation

Monolithic Stationary Phases Prepared by Ring-Opening Metathesis Polymerisation for cap-HPLC

Monolithic Stationary Phases Prepared by Ring-Opening Metathesis Polymerisation: Influence of Different Polymerisation Parameters on Separation Performance

Mögliche Hepatoselektivität von Insulin Detemir im Vergleich zu NPH Insulin in Patienten mit Typ-1-Diabetes

Particle-Loaded Monoliths for Enantioseparation by Capillary Electrochromatography

Protracted pharmacodynamic profile and high between-subject predictability with insulin detemir in subjects with type 1 diabetes

• A New Class of Continuous Rods as Stationary Phases Prepared by Ring-Opening Metathesis Polymerization: A Straight Forward Route to Functionalized Monoliths
• A new strategy for the sensitive and simultaneous analysis of human insulin and insulin analogues using LC/MS² in combination with a tailored sample clean-up procedure
• A novel minimally-invasive approach for investigations into skin barrier function and percutaneous drug penetration
• A Robust and Easy Method for Simultaneous Quantitation of Glucose and [6,6-d2] Glucose in Human Plasma using GC-MS
• A validated analytical method for the dermination of L-Cystine, N-Acetyl-L-Cysteine, L-Cysteine and rearrangement products in amino acid solutions by LC/MS/MS
• Activities and funding programmes for nanomedicine in Austria
• Acyl CoA-Profiling in Biological Tissues using Online SPE-LC-FTMS (Orbitrap)
• BioNanoNet
• Buccal permeability studies of nanostructured materials and the structural concept of the European Center for Nanotoxicology
• Chiral Polymer Supports Prepared via Ring-Opening Metathesis Graft-Polymerization. Scopes and Limitations
• Comparison of fenoprofen and deuterated ketoprofen as internal standards for ketoprofen analysis in microdialysis and open-flow microperfusion samples
• DAS INTERSTITIUM: EINE ANALYTISCHE HERAUSFORDERUNG
• DermAxess: Access to continuous in-vivo sampling in skin for realistic probes
• Development of Capillary-Scale Monolithic Supports for On-Line Sample Pre-treatment in Nanomedical Research
• Dipyridyl Amide-Functionalized Polymers by Ring-Opening-Metathesis Polymerization (ROMP) for the Selective Extraction of Mercury and Palladium
• Duration of action, pharmacodynamic profile and between-subject variability of insulin detemir in subjects with Type 1 diabetes
• Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase
• Enantioseparation of glycyl-dipeptides by CEC using particle-loaded monoliths prepared by ring-opening metathesis polymerization (ROMP).
• Enantioseparation of glycyl-dipeptides by CEC using particle-loaded monoliths prepared by ring-opening metathesis polymerization (ROMP).
• Euronanotox, The European Center for Nanotoxicology - An Austrian hub for Nanotoxicology
• European Center for Nanotoxicology: the Austrian Hub for Nanosafety
• European Center for Nanotoxicology:: the Austrian Hub for Nanosafety
• Evaluation of different techniques for subcutaneous glucose monitoring in type 1 diabetic patients during “real-life” glucose excursions
• Evaluation of ion-pairing reagents for phospholipid class separation by normal phase HPLC using negative electrospray ionization mass spectrometry detection
• Evaluation of norbornene-ß-cyclodextrin-based monomers and polymers as chiral selectors by means of non-aqueous capillary electrophoresis
• Evaluierung von Techniken zum subkutanen Glukosemonitoring bei Typ-1-Diabetikern
• Functional Monolithic Capillary Columns Prepared by Ring-Opening Metathesis Polymerizatio
• Functional Monolithic Capillary Columns Prepared by Ring-Opening Metathesis Polymerization
• Functional, ROMP-Based Materials for Life Sciences
• Functionalization of ROMP-derived monolithic capillary columns and their chromatographic properties
• Functionalized monolithic materials: syntheses, structures and use in life sciences, tissue engineering and heterogeneous catalysis
• Handhabung und Sicherheit von Nanopulvern
• Highly Efficient, Multifunctional Nanoparticle for Diagnostics
• Influence of different sample preparation techniques on the simultaneous quantification of different insulins in serum using cap-HPLC/MS2
• Insulin glulisine, insulin lispro and regular human insulin show comparable end-organ metabolic effects: an exploratory study.
• Ion-Exchange Monolithic Capillary Columns Prepared by Ring-Opening Metathesis Polymerization
• Ion-exchange monolithic stationary phases prepared by ring-opening metathesis polymerization
• Ionization efficiency of phospholipid classes in negative electrospray ionization mass spectrometry
• Kirk, Spock und die Medizintechnik Episode 2
• LC/MS/MS Method for Quantitative Determination of Long-Chain Fatty Acyl-CoAs
• Lipidomics Based Design of Novel Antimicrobial Peptides Against Methicillin-Resistant Staphylococcus Aureus
• Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access.
• Medical Sensor Solutions - a styrian Innovation Alliance
• Miniaturised Monolithic Pre-columns prepared by ROMP for On-line Clean-up of Crude Nanoparticle-containing Samples
• Monolithic capillary columns prepared by ring-opening metathesis polymerisation
• Monolithic Capillary Columns Prepared by Ring-Opening Metathesis Polymerization and their Application in Medical Research
• Monolithic Stationary Phases Prepared by Ring-Opening Metathesis Polymerisation for cap-HPLC
• Monolithic Stationary Phases Prepared by Ring-Opening Metathesis Polymerisation: Influence of Different Polymerisation Parameters on Separation Performance
• Mögliche Hepatoselektivität von Insulin Detemir im Vergleich zu NPH Insulin in Patienten mit Typ-1-Diabetes
• Nano Health: aims and results of a joint research project of the Austrian NANO-Initiative
• Nanomedicine – Opportunities und Drawbacks
• Nanomedizin: Chancen und Risiken
• Nanoscale Material: A new challenge for toxicology
• Nanotechnologie in der Medizin mit besonderem Focus auf mögliche gesundheitliche Auswirkungen
• Nanotechnologie: Chancen und Risiken
• Neue Trennphasen für duie klinische Forschung
• New Methods for Bioprocess Modeling and Monitoring: A Mulitdisciplinary Approach
• New nanoparticle-based approaches for in-vivo diagnostics and therapy
• New strategy for insulin andinsulin analogs quantification – MRM detection for insulin B chain
• Norbornene-based Monolithic Pre-Columns for LC/MS Analysis in Nanomedical Research
• Novel catheters for in vivo research and pharmeceutical trials providing direct access to extracellular space of target tissues
• Online SPE-LC/FTMS (Orbitrap) Technique for Metabolite Profiling (Acyl CoAS)
• Optimization of Norbornene-Based Monolithic Pre-Columns for their use in Nanomedical Research
• Particle-Loaded Monoliths for Enantioseparation by Capillary Electrochromatography
• Poly(Cyclooctene)-Based Monolithic Columns for µ-HPLC Prepared via Ring-Opening Metathesis Polymerization (ROMP)
• Potenzielle Gefahren für die menschliche Gesundheit von nanostrukturierten Materialien
• Profiling of Acyl CoAs in Biological Tissues using Online SPE-LC-FTMS (Orbitrap)
• Proportional dose-response relationship and lower within-patient variability of insulin detemir and NPH insulin in subjects with type 1 diabetes mellitus.
• Protracted pharmacodynamic profile and high between-subject predictability with insulin detemir in subjects with type 1 diabetes
• Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion.
• Ring-Opening Metathesis Polymerisation-derived Capillary Monoliths: Versatile Analytical Tools for Modern Biomedical Research
• Ring-Opening Metathesis Polymerisation-derived Capillary Monoltihs: Versatile Analytical Tools for Biomedical Research
• Ring-Opening Metathesis Polymerisation-derived Capillary Monoltihs: Versatile Analytical Tools for Modern Biomedical Research
• Ring-Opening Metathesis Polymerization for the Preparation of Functionalized Monolithic Stationary Phases used in Chromatography
• Ring-opening metathesis polymerization for the preparation of norbornene-based weak cation-exchange monolithic capillary columns.
• Ring-Opening Metathesis Polymerization for the Preparation of Surface-Grafted Polymer Supports
• Ring-opening metathesis polymerization-derived capillary monoliths: versatile analytical tools for modern biomedical research
• Ring-opening metathesis polymerization-derived capillary monoliths: versatile analytical tools for modern biomedical research
• Ring-opening metathesis polymerization-derived monolithic capillary columns for high-performance liquid chromatography. Downscaling and application in medical research
• Ringöffnende Metathesepolymerisation: Zugang zu einer neuen Klasse funktionalisierter, monolithischer stationärer Phasen für die Flüssigkeitschromatographie
• ROMP-based monolithic capillary columns as ESI-Interface for fast and sensitive LC-MS analysis
• Romp-based monolithic capillary columns for ion-exchange liquid chromatography
• ROMP-derived monolithic capillary pre-columns for on-line SPE of nanoparticles
• Searching for the optimal methodology for dermal in vivo sampling
• Searching for the optimal methodology for dermal in vivo sampling.
• Senstive insulin analysis in interstitial fluid: Influence of mobile phase additives on insulin B chain loading efficiency in CAP-HPLC/MS
• Strategies for Quantification of Insulin and Insulin Analogues by LC MS/MS
• Strategies for sensitive peptide detection in brain homogenate using LC/MS for the purpose of blood-brain-delivery testing
• Subcutaneous glucose monitoring in patients with severe sepsis
• Tailor-Made Polymer Supports via Metathesis Polymerization: Concept and Application
• The European Center of Nanotoxicology - An Austrian Activity
• The interstitium: an analytical challenge
• The Utility of ROMP for the Preparation of Functionalized Monoliths: Capillary Column Synthesis and their Separation Properties
• Ultrafiltration as a purification step in sample preparation for LC/MS² analysis of insulin in serum
• Validated Comprehensive Analytical Method for Quantification of Coenzyme-A Activated Compounds in Biological Tissues by Triple Quadrupol LC/MS/MS
• Voltage-assisted capillary LC of peptides using monolithic capillary columns prepared by ring-opening metathesis polymerization.