Testing and further development of dressing materials
In collaboration with JR-MATERIALS, QRSkin and the Fraunhofer Institute, the functionalization and extended use of EPICITE was further developed. This includes the loading of dressing materials with antiseptics in order to prevent wound infections as well as with indicators to enable a ealier diagnosis of the respective wound infections.
The testing of dressing materials is carried out in cooperation with the Medical University of Graz, the Division for Plastic, Aesthetic and Reconstructive Surgery, and covers:
- Preclinical and clinical testing
- Preclinical testing using in vitro, ex vivo and in vivo models
- Evaluation of wound healing using comparable evaluation methods for clinical and preclinical research
- Wound documentation (3D photography including planimetry and volumetry)
- Characterization of the skin perfusion (laser speckle contrast imaging, hyperspectral camera, thermal imaging camera)
Holzer JCJ, Tiffner K, Kainz S, Reisenegger P, Bernardelli de Mattos I, Funk M, Lemarchand T, Laaff H, Bal A, Birngruber T, Kotzbeck P, Kamolz LP. A novel human ex-vivo burn model and the local cooling effect of a bacterial nanocellulose-based wound dressing. Burns. 2020 Dec;46(8):1924-1932. doi: 10.1016/j.burns.2020.06.024. Epub 2020 Jul 3.
Bernardelli de Mattos I, Nischwitz SP, Tuca AC, Groeber-Becker F, Funk M, Birngruber T, Mautner SI, Kamolz LP, Holzer JCJ. Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine. Burns. 2020 Jun;46(4):918-927. doi: 10.1016/j.burns.2019.10.006. Epub 2019 Oct 23.
Nischwitz SP, Bernardelli de Mattos I, Hofmann E, Groeber-Becker F, Funk M, Mohr GJ, Branski LK, Mautner SI, Kamolz LP. Continuous pH monitoring in wounds using a composite indicator dressing - A feasibility study. Burns. 2019 Sep;45(6):1336-1341. doi: 10.1016/j.burns.2019.02.021. Epub 2019 Jul 30.