Health
Dr Thomas Birngruber
Health
Neue Stiftingtalstraße 2
8010 Graz
Österreich
publications
- Dermal open flow microperfusion for PK-based clinical bioequivalence studies of topical drug products
- Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs
- The Impact of Prolonged Inflammation on Wound Healing
- miRNAs as Regulators of the Early Local Response to Burn Injuries
- miRNAs as Regulators of the Early Local Response to Burn Injuries.
- Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging
- Dermal sampling techniques with focus on dermal Open Flow Microperfusion
- OFM-recirculation and OFM-suction: advanced in-vivo open flow microperfusion (OFM) methods for direct and absolute quantification of albumin in interstitial fluid
- A novel human ex vivo skin model to study early local responses to burn injuries
- A novel human ex vivo skin model to study early local responses to burn injuries
- A novel human ex-vivo burn model and the local cooling effect of a bacterial nanocellulose-based wound dressing
- Evaluating Dermal Pharmacokinetics and Pharmacodymanic Effect of Soft Topical PDE4 Inhibitors: Open Flow Microperfusion and Skin Biopsies
- OFM recirculation and OFM suction: Advanced in-vivo open flow microperfusion methods for direct and absolute quantification of albumin in interstitial fluid
- Variability of Skin Pharmacokinetic Data: Insights from a Topical Bioequivalence Study Using Dermal Open Flow Microperfusion
- A novel human ex-vivo burn model and the local cooling effect of a bacterial nanocellulose-based wound dressing
- Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine
- Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine
- Choice and characterization of preclinical models - Towards understanding wound healing
- Corrigendum to "Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood-brain barrier in leptin resistant mice" [Molecular Metabolism 13 (2018) 77-82
- Choice and characterization of preclinical models — Towards understanding wound healing
- Insulin Distribution in Human Adipose Tissue via a Novel Insulin Infusion Catheter
- Clinical Study Design to Evaluate Whether the Systemic Bioavailability of Topical Drugs May Influence the Assessment of Local Dermal Pharmacokinetics by Dermal Open Flow Microperfusion (dOFM)
- Open flow microperfusion (OFM) – a tool for in vivo metabolic profiling of adipose tissue
- Dermal pharmacokinetic endpoint studies to evaluate bioequivalence of topically applied lidocaine and prilocaine drug products
- Variability of topical penetration data from Dermal Open Flow Microperfusion might be attributed to variability in skin barrier function and follicular penetration
- Extracellular Vesicles in Human Skin: Cross-Talk from Senescent Fibroblasts to Keratinocytes by miRNAs.
- Cerebral Open Flow Microperfusion to Monitor Drug Transport Across the Blood‐Brain Barrier
- LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation
- Cerebral open flow microperfusion (cOFM) – long-term sampling of cerebral interstitial and cerebrospinal fluid
- Topical application of haemoglobin: a safety study
- Comparison of cerebral Open Flow Microperfusion and Microdialysis when sampling small lipophilic and small hydrophilic substances
- Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine
- Einfluss von sekundären Wundauflagen auf die Wirkung von Epicite Hydro: Ergebnisse einer Tierexperimentellen Studie
- Granulox: Eine Safety Studie
- Die Aufnahme von PHMB in epicite: eine Studie zur klinischen Anwendbarkeit
- Determination of eicosanoids by UHPLC-MS/MS in diluted interstitial fluid sampled with open flow microperfusion
- Dermal open flow microperfusion: Sampling of interstitial fluid directly from the dermis for pharmacokinetic and pharmacodynamic evaluations
- Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood-brain barrier in leptin resistant mice.
- Variability of topical penetration data: what do we learn from a bioequivalence study using dermal open flow microperfusion
- Uptake of PHMB in a bacterial nanocellulose-based wound dressing: A feasible clinical procedure
- Evaluation of the Psoriasis-like Inflammation in the Imiquimod Rat Modelusing Dermal Open Flow Microperfusion
- Continuous Sampling of Immune Cells in the
- Investigation of Protein Binding in Skin with Dermal Open Flow Microperfusion (dOFM)
- Local Inflammatory Response after Topically Applied Burn Stimuli Investigated in Excised Human Skin
- In Vivo Dermal Open Flow Microperfusion: Understanding and Controlling Sources of Variability to Evaluate Topical Bioequivalence
- Development of a LC-MS method for quantification of six common pharmaceuticals in OFM samples
- Chronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system
- Quantification of Basal Insulin Peglispro and Human Insulin in Adipose Tissue Interstitial Fluid by Open-Flow Microperfusion.
- Assessment of insulin distribution in subcotanous adipose tissue when using novel insulin
- Continuous Sampling of Immune Cells Using Open Flow Microperfusion
- Interstitial fluid sampling with open flow microperfusion for investigation of protein binding in tissue
- Monitoring leptin concentration in the hypothalamus with intact blood-brain barrier using cerebral open-flow microperfusion (cOFM)
- Determination of (2)H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography - quadrupole-mass-spectrometry.
- cOFM cerebral open flow microperfusion
- Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence
- Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue
- Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence
- in-vivo open flow microperfusion
- Open Flow Microperfusion as Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence
- Open flow microperfusion - a new tool to investigate the brain-fat axis
- Organ specific biomarker research in-vivo
- Cerebral Open Flow Microperfusion (cOFM): Long Term In Vivo Monitoring of Transport across the Intact BBB
- Open Flow Microperfusion as Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence
- Impact of local inflammation and blood-brain barrier (BBB) impairment: comparison of In vivo microdialysis and cerebral open flow microperfusion (cOFM) methods for the detection of cytokines
- A new focal EAE model using a permanent cOFM interface
- Cerebral Open Flow Microperfusion (cOFM) enables quantification of enhanced transport of brain-targeted nanocarriers across the intact blood-brain barrier
- Assessment of Blood-Brain Barrier Function and the Neuroinflammatory Response in the Rat Brain by Using Cerebral Open Flow Microperfusion (cOFM)
- Enhanced doxorubicin delivery to the brain administered through glutathione PEGylated liposomal doxorubicin (2B3-101) as compared with generic Caelyx,(®)/Doxil(®)--a cerebral open flow microperfusion pilot study.
- Long-Term Implanted cOFM Probe Causes Minimal Tissue Reaction in the Brain
- In Vitro and In Vivo Techniques to Assess Neurotoxicity of Nanoparticles
- Enhanced absorption of insulin aspart due to a dispersed injection strategy tested in a randomized trial in type 1 diabetes patients
- A new model of focal inflammatory demyelination in the neocortex of the rat
- Cerebral open flow microperfusion: A new in vivo technique for continuous measurement of substance transport across the intact blood-brain barrier
- Certified dOFM sampling devices provide access to target tissue in pharmaceutical trials
- Clinical applicability of dOFM devices for dermal sampling
- Open Flow Microperfusion: An Alternative Method to Microdialysis?
- Novel catheters for in vivo research and pharmeceutical trials providing direct access to extracellular space of target tissues
- Comparison of Microdialysis and Microperfusion for efficient in vivo research on dermal barrier function and penetration.