Health
Dr Manfred Bodenlenz
Health
Neue Stiftingtalstraße 2
8010 Graz
Österreich
publications
- Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging
- Variability of Skin Pharmacokinetic Data: Insights from a Topical Bioequivalence Study Using Dermal Open Flow Microperfusion
- Clinical Study Design to Evaluate Whether the Systemic Bioavailability of Topical Drugs May Influence the Assessment of Local Dermal Pharmacokinetics by Dermal Open Flow Microperfusion (dOFM)
- Dermal pharmacokinetic endpoint studies to evaluate bioequivalence of topically applied lidocaine and prilocaine drug products
- Variability of topical penetration data from Dermal Open Flow Microperfusion might be attributed to variability in skin barrier function and follicular penetration
- LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation
- Determination of eicosanoids by UHPLC-MS/MS in diluted interstitial fluid sampled with open flow microperfusion
- Dermal open flow microperfusion: Sampling of interstitial fluid directly from the dermis for pharmacokinetic and pharmacodynamic evaluations
- Bioequivalence of Topical Products in Excised Human Skin Assessed with dermal Open Flow Microperfusion
- Variability of topical penetration data: what do we learn from a bioequivalence study using dermal open flow microperfusion
- Continuous Sampling of Immune Cells Using Open Flow Microperfusion
- Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence
- ß -Defensin 2 is a responsive biomarker of IL-17A-driven skin pathology in patients with psoriasis
- the use of membrane free OFM for studies into the PK-PD of large molecules
- Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence
- Secukinumab Treatment Rapidly Leads to Positive Proteomic and Transcriptional Changes in Psoriatic Skin
- Open Flow Microperfusion as Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence
- Open Flow Microperfusion as Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence
- Secukinumab Treatment Rapidly Leads to Positive Proteomic and Transcriptional Changes in Psoriatic Skin
- Secukinumab Distributes into Dermal Interstitial Fluid of Psoriasis Patients as Demonstrated by Open Flow Microperfusion
- Bioavailability of insulin detemir and human insulin at the level of peripheral interstitial fluid in humans assessed by open flow microperfusion
- Secukinumab Rapidly Reduces Markers of Both Keratinocyte Proliferation and Skin Integrity in Psoriasis
- Novel method for determining eicosanoids in the interstitial fluid of psoriatic skin
- Secukinumab Treatment Rapidly Leads to Positive Proteomic and Transcriptional Changes in Psoriatic Skin
- Entwicklung und Validierung einer UHPLC-MS/MS Methode zur Ermittlung der Pharmakokinetik von antiviralen Aciclovir-Cremen
- Treatment with Secukinumab Rapidly Leads to Positive Proteaomic and Transcriptional Changes in Psoriatic Skin
- Dermal open flow microperfusion illustrates the topical penetration of clobetasol-17-propionate into psoriatic lesional and non-lesional skin with time and space
- An analytical method (UHPLC-MS/MS) to determine the pharmacodynamic behavior of the topically applied antiviral
- Novel skin microperfusion demonstrates that psoriasis lesional skin contains higher protein levels of IL-17A and IL-17AF, but not IL-17F compared to non-lesional skin
- Secukinumab, a novel anti-IL-17A antibody, can be quantified in skin after a single dose by dermal open flow microperfusion (dOFM)
- The anti IL-17A IgG1 antibody distributes in dermal interstitial fluid as demonstrated by using dermal open flow microperfusion after a single 300 mg subcutaneous administration; assessment in healthy volunteers and patients with moderate-to-severe plaque
- Absolute levels of the novel anti-IL-17A antibody, secukinumab, in skin can be quantified by dermal open flow microperfusion (dOFM)
- Certified dOFM sampling devices provide access to target tissue in pharmaceutical trials
- Clinical applicability of dOFM devices for dermal sampling
- Open Flow Microperfusion: An Alternative Method to Microdialysis?
- Periodic Extraction of Interstitial Fluid from the Site of Subcutaneous Insulin Infusion for the Measurement of Glucose: A Novel Single-Port Technique for the Treatment of Type 1 Diabetes Patients
- Skin impedance measurements support ex-vivo penetration studies for topical applied drugs
- Comparison of open-flow microperfusion and microdialysis methodologies when sampling topically applied fentanyl and benzoic acid in human dermis ex vivo.
- Dermal open-flow microperfusion as a novel technique for in vivo measurement of dermal interstitium
- Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling
- Periodic extraction of interstitial fluid from the site of subcutaneous insulin infusion for the measurement of glucose: A novel single-port technique for the treatment of type 1 diabetes patients.
- Novel catheters for in vivo research and pharmeceutical trials providing direct access to extracellular space of target tissues
- Searching for the optimal methodology for dermal in vivo sampling.
- Interleukin-6 produced in subcutaneous adipose tissue is linked to blood pressure control in septic patients.
- Comparison of Microdialysis and Microperfusion for efficient in vivo research on dermal barrier function and penetration.
- A novel automated discontinuous venous blood monitoring system for ex vivo glucose determination in humans.
- An Automated Discontinious Venous Blood Sampling System for Ex Vivo Glucose Determination in Humans
- A novel automated discontinuous venous blood monitoring system for ex vivo glucose determination in humans
- An automated discontinuous venous blood sampling system for ex vivo glucose determination in humans.
- Clinical Evaluation of Subcutaneous Lactate Measurement in Patients after Major Cardiac Surgery
- Clinical evaluation of subcutaneous lactate measurement in patients after major cardiac surgery.
- Two new approaches using the Error Grid Analysis
- A novel minimally-invasive approach for investigations into skin barrier function and percutaneous drug penetration
- Insulin glulisine, insulin lispro and regular human insulin show comparable end-organ metabolic effects: an exploratory study.
- Open-Flow Microperfusion (OFM): An alternative method for high-MW and lipophilic sampling
- Subcutaneous adipose tissue exerts proinflammatory cytokines after minimal trauma in humans.
- Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion.
- Subcutaneous glucose monitoring in patients with severe sepsis
- Bed-side monitoring of subcutaneous interstitial glucose in healthy individuals using microdialysis and infrared spectrometry
- Bedside monitoring of subcutaneous interstitial glucose in healthy individuals using microdialysis and infrared spectrometry.
- Inflammatory Cytokine Response of Subcutaneous Adipose Tissue after Minimal Trauma in Humans
- Local stimulated secretion of inflammatory cytokines from adipose tissue is reduced in septic patients in comparison to healthy controls
- Monitoring blood glucose with microdialysis of interstitial fluid in critically ill children.
- Proportional dose-response relationship and lower within-patient variability of insulin detemir and NPH insulin in subjects with type 1 diabetes mellitus.
- Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion.
- Subcutaneous adipose tissue exerts proinflammatory cytokines after minimal trauma in humans
- System for automated discontinuous venous blood withdrawal for glucose determination of patients at the ICU
- Automatisches diskontinuierliches System zur venösen Blutabnahme für die Blutzuckerbestimmung bei Intensivpatienten
- Bed-side monitoring of subcutaneous interstitial glucose and metabolites in healthy and diabetic subjects using microdialysis and infrared spectrometry
- Clinical evaluation of subcutaneous glucose monitoring in patients with severe sepsis
- Comparison of fenoprofen and deuterated ketoprofen as internal standards for ketoprofen analysis in microdialysis and open-flow microperfusion samples
- Continuous Lactate Monitoring during Exercise by Means of a Portable Device
- Continuous Metabolite Monitoring during Exercise by Means of Dermal Sampling and a Portable Device
- Direkte Messung des Effektes von Insulin auf die Sekretion von proinflammatorischen Zytokinen im subkutanen Fettgewebe beim Menschen
- Evaluation of subcutaneous glucose measurements in patients with severe sepsis
- Glukosemessung und Insulin-Infusionsgeräte
- Kontinuierliches Glukosemonitoring bei Intensivpatienten mit Hilfe der Mikrodialyse in Vollblut
- Kontinuierliches Laktatmonitoring bei sportlicher Belastung
- Kontinuierliches Monitoring bei körperlicher Aktivität mittels tragbarem Gerät und dermalem Katheter
- Manuelle Blutentnahme bei klinischen Studien in der Diabetesforschung: Ist die herkömmliche Referenzmethode zuverlässig?
- On-line adaptive algorithm with glucose prediction capacity for subcutaneous closed loop control of glucose: evaluation under fasting conditions in patients with Type 1 diabetes.
- On-line adaptive algorithm with glucose prediction capacity for subcutaneous closed loop control of glucose: evaluation under fasting conditions in patients with Type 1 diabetes.
- Reduced local inflammatory reactivity in septic patients compared to healthy controls
- Subkutanes Glukosemonitoring in Patienten mit schwerer Sepsis
- Untersuchung des Effektes Physiologischer Hyperinsulinämie auf den Zugang von Makromolekülen zu insulin-sensitiven Geweben
- Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access.
- A double-blind, randomized, dose-response study investigating the pharmacodynamic and pharmacokinetic properties of the long-acting insulin analog detemir.
- Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access.
- Closing the Loop: The Adicol Experience
- Closing the loop: the adicol experience.
- Interstitial glucose kinetics in subjects with type 1 diabetes under physiologic conditions
- Mögliche Hepatoselektivität von Insulin Detemir im Vergleich zu NPH Insulin in Patienten mit Typ-1-Diabetes