{"id":21611,"date":"2026-03-01T09:59:13","date_gmt":"2026-03-01T08:59:13","guid":{"rendered":"https:\/\/www.joanneum.at\/ofm\/?page_id=21611"},"modified":"2026-03-02T15:49:49","modified_gmt":"2026-03-02T14:49:49","slug":"ofm-publications","status":"publish","type":"page","link":"https:\/\/www.joanneum.at\/ofm\/ofm-publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\t\t
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Publications<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Our scientific contributions to the evolution of OFM<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\tFind out more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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aOFM<\/h2>\r\n\r\n

Predicting human subcutaneous bioavailability of monoclonal antibodies using an open flow microperfusion porcine model<\/h3>\r\n

Schwagerle, G., Bonan, R. H., Milewski, M., Sanchez-Felix, M., Mittal, S., Kapur, S., Abbou Oucherif, K., Hsiao, W.-K., Wiltschko, L., Mautner, S. I., van Daele, J., Fabre, M.-A., Shivaraju, M., Annaert, P., Birngruber, T., & Venczel, M. (2026)
\r\nDOI: 10.1016\/j.jconrel.2025.114401<\/a><\/p>\r\n
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Topical Delivery Systems Effectively Transport Analgesics to Areas of Localized Pain via Direct Diffusion<\/h3>\r\n

Birngruber, T., Vought, K., Schwingenschuh, S., Reisenegger, P., Maibach, H., & Lissin, D. (2023)
\r\nDOI: 10.3390\/pharmaceutics15112563<\/a><\/p>\r\n
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OFM recirculation and OFM suction: Advanced in-vivo open flow microperfusion methods for direct and absolute quantification of albumin in interstitial fluid<\/h3>\r\n

Hummer, J., Schwingenschuh, S., Raml, R., Boulgaropoulos, B., Schwagerle, G., Augustin, T., Sinner, F., & Birngruber, T. (2020)
\r\nDOI: 10.1088\/2057-1976\/abc3a7<\/a><\/p>\r\n\r\n

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cOFM<\/h2>\r\n\r\n

Cerebral open flow microperfusion (cOFM)-HILIC-HRMS platform for in vivo and in situ monitoring of tumor microenvironment in glioblastoma<\/h3>\r\n

Monedeiro, F., Schimek, D., Prugger, E. M., Altendorfer-Kroath, T., Z\u00fcgner, E., & Magnes, C. (2025)
\r\nDOI: 10.1016\/j.aca.2025.344183<\/a><\/p>\r\n
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In Vitro and In Vivo Techniques to Assess Neurotoxicity of Nanoparticles<\/h3>\r\n

Birngruber, T., Okereke, J., Shapovalov, V., Fr\u00f6hlich, E., Sinner, F., Yu, J. S., Hsieh, M., Kateb, B., & Pieber, T. R. (2024)
\r\nDOI: 10.1007\/978-3-030-80662-0_33<\/a><\/p>\r\n
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Quantification of the Therapeutic Antibody Ocrelizumab in Mouse Brain Interstitial Fluid Using Cerebral Open Flow Microperfusion and Simultaneous Monitoring of the Blood\u2013Brain Barrier Integrity<\/h3>\r\n

Altendorfer-Kroath, T., Hummer, J., Kollmann, D., Boulgaropoulos, B., Raml, R., & Birngruber, T. (2023)
\r\nDOI: 10.3390\/pharmaceutics15071880<\/a><\/p>\r\n
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In vivo monitoring of brain pharmacokinetics and pharmacodynamics with cerebral open flow microperfusion<\/h3>\r\n

Altendorfer\u2010Kroath, T., Hummer, J., & Birngruber, T. (2023)
\r\nDOI: 10.1002\/bdd.2343<\/a><\/p>\r\n
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Atraumatic access to human glioblastoma in a xenograft animal model by cerebral open flow microperfusion<\/h3>\r\n

Altendorfer-Kroath, T., Asslaber, M., Hummer, J., Boulgaropoulos, B., Prietl, B., Pieber, T. R., Bernhart, E., & Birngruber, T. (2023)
\r\nDOI: 10.1016\/j.jneumeth.2023.109893<\/a><\/p>\r\n\r\n

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dOFM<\/h2>\n\n

Open flow microperfusion to assess local drug concentrations in the buccal mucosa<\/h3>\n

Wiltschko, L., Fischer, P., Schwingenschuh, S., Raml, R., Raber, G., Birngruber, T., & Roblegg, E. (2025)
\nDOI: 10.1016\/j.jpha.2024.101135<\/a><\/p>\n
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Impact of protein binding on drug sampling by microdialysis and open flow microperfusion<\/h3>\n

Wiltschko, L., Schwingenschuh, S., Reisenegger, P., Eder, S., Bodenlenz, M., Roblegg, E., Birngruber, T., & Raml, R. (2025)
\nDOI: 10.1016\/j.jddst.2025.107038<\/a><\/p>\n
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Opportunities of topical drug products in a changing dermatological landscape. European Journal of Pharmaceutical Sciences<\/h3>\n

Hsiao, W.-K., Herbig, M. E., Newsam, J. M., Gottwald, U., May, E., Winckle, G., & Birngruber, T. (2024)
\nDOI: 10.1016\/j.ejps.2024.106913<\/a><\/p>\n
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Cutaneous pharmacokinetics-based bioequivalence: A clinical dermal open flow microperfusion verification study using lidocaine and prilocaine combination topical products<\/h3>\n

Tiffner, K. I., Ramezanli, T., Boulgaropoulos, B., Birngruber, T., Bodenlenz, M., Lackner, B. C., Raml, R., Jiang, Y., Raney, S. G., & Sinner, F. (2024)
\nDOI: 10.1016\/j.ejps.2024.106827<\/a><\/p>\n
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Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopic Dermatitis<\/h3>\n

Monedeiro, F., Ehall, B., Tiffner, K. I., Eberl, A., Svehlikova, E., Prietl, B., Pfeifer, V., Senekowitsch, J., Remm, A., Rebane, A., Magnes, C., Pieber, T., Sinner, F., & Birngruber, T. (2024)
\nDOI: 10.1021\/acs.jproteome.4c00153<\/a><\/p>\n
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Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs<\/h3>\n

Hummer, J., Birngruber, T., Sinner, F., Page, L., Toner, F., Roper, C. S., Moore, D. J., Baker, M. B., & Boncheva Bettex, M. (2022)
\nDOI: 10.1016\/j.ijpharm.2022.121737<\/a><\/p>\n
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Dermal open flow microperfusion for PK-based clinical bioequivalence studies of topical drug products<\/h3>\n

Birngruber, T., Tiffner, K. I., Mautner, S. I., & Sinner, F. M. (2022)
\nDOI: 10.3389\/fphar.2022.1061178<\/a><\/p>\n
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Advanced Online Monitoring of In Vitro Human 3D Full-Thickness Skin Equivalents<\/h3>\n

Schaller-Ammann, R., Kre\u00df, S., Feiel, J., Schwagerle, G., Priedl, J., Birngruber, T., Kasper, C., & Egger, D. (2022)
\nDOI: 10.3390\/pharmaceutics14071436<\/a><\/p>\n
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Dermal sampling techniques with focus on dermal Open Flow Microperfusion<\/h3>\n

Schwagerle, G., Bonan, R. H., Milewski, M., Sanchez-Felix, M., Mittal, S., Kapur, S., Abbou Oucherif, K., Hsiao, W.-K., Wiltschko, L., Mautner, S. I., van Daele, J., Fabre, M.-A., Shivaraju, M., Annaert, P., Birngruber, T., & Venczel, M. (2026)
\nDOI: 10.1016\/j.jconrel.2025.114401<\/a><\/p>\n
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Variability of Skin Pharmacokinetic Data: Insights from a Topical Bioequivalence Study Using Dermal Open Flow Microperfusion<\/h3>\n

Bodenlenz, M., Augustin, T., Birngruber, T., Tiffner, K. I., Boulgaropoulos, B., Schwingenschuh, S., Raney, S. G., Rantou, E., & Sinner, F. (2020)
\nDOI: 10.1007\/s11095-020-02920-x<\/a><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Publications Our scientific contributions to the evolution of OFM \u00a0 Find out more aOFM Predicting human subcutaneous bioavailability of monoclonal antibodies using an open flow microperfusion porcine model Schwagerle, G., Bonan, R. H., Milewski, M., Sanchez-Felix, M., Mittal, S., Kapur, S., Abbou Oucherif, K., Hsiao, W.-K., Wiltschko, L., Mautner, S. I., van Daele, J., Fabre, […]<\/p>\n","protected":false},"author":84,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-21611","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.joanneum.at\/ofm\/wp-json\/wp\/v2\/pages\/21611","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.joanneum.at\/ofm\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.joanneum.at\/ofm\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.joanneum.at\/ofm\/wp-json\/wp\/v2\/users\/84"}],"replies":[{"embeddable":true,"href":"https:\/\/www.joanneum.at\/ofm\/wp-json\/wp\/v2\/comments?post=21611"}],"version-history":[{"count":7,"href":"https:\/\/www.joanneum.at\/ofm\/wp-json\/wp\/v2\/pages\/21611\/revisions"}],"predecessor-version":[{"id":21651,"href":"https:\/\/www.joanneum.at\/ofm\/wp-json\/wp\/v2\/pages\/21611\/revisions\/21651"}],"wp:attachment":[{"href":"https:\/\/www.joanneum.at\/ofm\/wp-json\/wp\/v2\/media?parent=21611"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}