TraceFATT
PROJECT DURATION:
01/2019
—
12/2021
Photo: JOANNEUM RESEARCH/Bergmann
The Project
Obesity is one of the biggest challenges for the health economy in the coming decades. New therapies with pharmaceutical hybrid active ingredients, which combine the functions of several active ingredients in one molecule, represent a first breakthrough in the fight against the obesity epidemic.
Our Role in the Project
In this project, HEALTH (Bioanalytics and Metabolomics) researched methods to reduce the body weight of obese people, in cases where pure behavioural changes of those affected do not achieve satisfactory results and operations are too risky. A new technology for these investigations is the so-called stable isotope tracer technology. Stable isotope-labelled metabolites were used to determine metabolic turnover rates and make statements about glucose turnover.
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Project Details
In TraceFATT-2, the follow-up project to the project of the same name in the 2016-2018 funding period, the promising developments of the previous project will be completed and the effect of new active substances on adipose tissue and energy metabolism will be investigated in preclinical studies. A combination of open microperfusion (OFM) and metabolomics will be used for the analyses. In addition, a combination of nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) will be implemented to investigate metabolism and will be used in the preclinical studies and in a sample subset of the clinical landmark study "EXSCEL "2 (cooperation with Oxford Center for Diabetes, Endocrinology and Metabolism). The data obtained can be used to determine which active ingredients "work" when and how in adipose tissue in order to achieve optimal combinations of active ingredients.
Within the framework of TraceFATT and TraceFATT-2, the HEALTH Institute has set itself the long-term goal of making essential contributions to the optimization of therapeutic approaches based on new combinations of active ingredients and to contribute to the development of treatment strategies with as few side effects as possible.
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