• Menu menu
  • menu Menü öffnen
Projekte -  

Complete Pharmacokinetics of Topical Analgesics

Drug transport into muscle tissue after application of an analgesic patch

The Project

Topical application of analgesics for lower back pain offers advantages such as site-specific application and lower daily doses. However, there is a lack of data showing the deep penetration of the active ingredients into the muscle. The client would like to determine the time-resolved drug profile of lidocaine using a novel topical delivery system (TDS or patch) to deliver the drug through the dermis and subcutis into the muscle tissue.

Our Role in the Project

HEALTH carried out a preclinical open flow microperfusion (OFM) study using a porcine model, which monitored drug concentrations in the dermis, subcutaneous adipose tissue, and muscle at application sites of a TDS containing lidocaine or diclofenac.

OFM data provided a comprehensive and extremely detailed insight into all relevant lidocaine transport pathways and clearly showed for the first time that topically applied lidocaine can actually reach the deeper muscle tissue via the local diffusion mechanism and not - as previously assumed - via the bloodstream.

Keine Datei zugewiesen.

Scilex Pharmaceuticals

Medizinische Universität Graz

Project Details

Birngruber, T., Vought, K., Schwingenschuh, S., Reisenegger, P., Maibach, H., & Lissin, D. (2023). Topical Delivery Systems Effectively Transport Analgesics to Areas of Localized Pain via Direct Diffusion. Pharmaceutics, 15(11), 2563. doi: 10.3390/pharmaceutics15112563


Related Projects

Skip to content