aOFM
Predicting human subcutaneous bioavailability of monoclonal antibodies using an open flow microperfusion porcine model
Schwagerle, G., Bonan, R. H., Milewski, M., Sanchez-Felix, M., Mittal, S., Kapur, S., Abbou Oucherif, K., Hsiao, W.-K., Wiltschko, L., Mautner, S. I., van Daele, J., Fabre, M.-A., Shivaraju, M., Annaert, P., Birngruber, T., & Venczel, M. (2026)
DOI: 10.1016/j.jconrel.2025.114401
Topical Delivery Systems Effectively Transport Analgesics to Areas of Localized Pain via Direct Diffusion
Birngruber, T., Vought, K., Schwingenschuh, S., Reisenegger, P., Maibach, H., & Lissin, D. (2023)
DOI: 10.3390/pharmaceutics15112563
OFM recirculation and OFM suction: Advanced in-vivo open flow microperfusion methods for direct and absolute quantification of albumin in interstitial fluid
Hummer, J., Schwingenschuh, S., Raml, R., Boulgaropoulos, B., Schwagerle, G., Augustin, T., Sinner, F., & Birngruber, T. (2020)
DOI: 10.1088/2057-1976/abc3a7
cOFM
Cerebral open flow microperfusion (cOFM)-HILIC-HRMS platform for in vivo and in situ monitoring of tumor microenvironment in glioblastoma
Monedeiro, F., Schimek, D., Prugger, E. M., Altendorfer-Kroath, T., Zügner, E., & Magnes, C. (2025)
DOI: 10.1016/j.aca.2025.344183
In Vitro and In Vivo Techniques to Assess Neurotoxicity of Nanoparticles
Birngruber, T., Okereke, J., Shapovalov, V., Fröhlich, E., Sinner, F., Yu, J. S., Hsieh, M., Kateb, B., & Pieber, T. R. (2024)
DOI: 10.1007/978-3-030-80662-0_33
Quantification of the Therapeutic Antibody Ocrelizumab in Mouse Brain Interstitial Fluid Using Cerebral Open Flow Microperfusion and Simultaneous Monitoring of the Blood–Brain Barrier Integrity
Altendorfer-Kroath, T., Hummer, J., Kollmann, D., Boulgaropoulos, B., Raml, R., & Birngruber, T. (2023)
DOI: 10.3390/pharmaceutics15071880
In vivo monitoring of brain pharmacokinetics and pharmacodynamics with cerebral open flow microperfusion
Altendorfer‐Kroath, T., Hummer, J., & Birngruber, T. (2023)
DOI: 10.1002/bdd.2343
Atraumatic access to human glioblastoma in a xenograft animal model by cerebral open flow microperfusion
Altendorfer-Kroath, T., Asslaber, M., Hummer, J., Boulgaropoulos, B., Prietl, B., Pieber, T. R., Bernhart, E., & Birngruber, T. (2023)
DOI: 10.1016/j.jneumeth.2023.109893
dOFM
Open flow microperfusion to assess local drug concentrations in the buccal mucosa
Wiltschko, L., Fischer, P., Schwingenschuh, S., Raml, R., Raber, G., Birngruber, T., & Roblegg, E. (2025)
DOI: 10.1016/j.jpha.2024.101135
Impact of protein binding on drug sampling by microdialysis and open flow microperfusion
Wiltschko, L., Schwingenschuh, S., Reisenegger, P., Eder, S., Bodenlenz, M., Roblegg, E., Birngruber, T., & Raml, R. (2025)
DOI: 10.1016/j.jddst.2025.107038
Opportunities of topical drug products in a changing dermatological landscape. European Journal of Pharmaceutical Sciences
Hsiao, W.-K., Herbig, M. E., Newsam, J. M., Gottwald, U., May, E., Winckle, G., & Birngruber, T. (2024)
DOI: 10.1016/j.ejps.2024.106913
Cutaneous pharmacokinetics-based bioequivalence: A clinical dermal open flow microperfusion verification study using lidocaine and prilocaine combination topical products
Tiffner, K. I., Ramezanli, T., Boulgaropoulos, B., Birngruber, T., Bodenlenz, M., Lackner, B. C., Raml, R., Jiang, Y., Raney, S. G., & Sinner, F. (2024)
DOI: 10.1016/j.ejps.2024.106827
Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopic Dermatitis
Monedeiro, F., Ehall, B., Tiffner, K. I., Eberl, A., Svehlikova, E., Prietl, B., Pfeifer, V., Senekowitsch, J., Remm, A., Rebane, A., Magnes, C., Pieber, T., Sinner, F., & Birngruber, T. (2024)
DOI: 10.1021/acs.jproteome.4c00153
Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs
Hummer, J., Birngruber, T., Sinner, F., Page, L., Toner, F., Roper, C. S., Moore, D. J., Baker, M. B., & Boncheva Bettex, M. (2022)
DOI: 10.1016/j.ijpharm.2022.121737
Dermal open flow microperfusion for PK-based clinical bioequivalence studies of topical drug products
Birngruber, T., Tiffner, K. I., Mautner, S. I., & Sinner, F. M. (2022)
DOI: 10.3389/fphar.2022.1061178
Advanced Online Monitoring of In Vitro Human 3D Full-Thickness Skin Equivalents
Schaller-Ammann, R., Kreß, S., Feiel, J., Schwagerle, G., Priedl, J., Birngruber, T., Kasper, C., & Egger, D. (2022)
DOI: 10.3390/pharmaceutics14071436
Dermal sampling techniques with focus on dermal Open Flow Microperfusion
Schwagerle, G., Bonan, R. H., Milewski, M., Sanchez-Felix, M., Mittal, S., Kapur, S., Abbou Oucherif, K., Hsiao, W.-K., Wiltschko, L., Mautner, S. I., van Daele, J., Fabre, M.-A., Shivaraju, M., Annaert, P., Birngruber, T., & Venczel, M. (2026)
DOI: 10.1016/j.jconrel.2025.114401
Variability of Skin Pharmacokinetic Data: Insights from a Topical Bioequivalence Study Using Dermal Open Flow Microperfusion
Bodenlenz, M., Augustin, T., Birngruber, T., Tiffner, K. I., Boulgaropoulos, B., Schwingenschuh, S., Raney, S. G., Rantou, E., & Sinner, F. (2020)
DOI: 10.1007/s11095-020-02920-x
