An ex-vivo human skin model which includes OFM-based sample collection is used to study local responses to external stimuli such as burns and topical treatments.
Assessing Bioequivalence of Topical Drugs
OFM was successfully used to determine the bioequivalence and non-bioequivalence of hydrophilic topical creams directly in the skin in an FDA-funded project supporting topical generic drug development.
Tracing Metabolic Pathways for New Obesity Therapies
Stable isotope tracer technology combined with OFM and metabolomics is used to investigate how novel active‑ingredient combinations act on adipose tissue and energy metabolism.
Mapping Biomarkers in Atopic Dermatitis
dermal OFM and metabolomics were used to uncover biomarker patterns in the skin of atopic dermatitis patients advancing personalized therapy decisions.
Monitoring Nanoparticle Penetration in the Skin
OFM was used to monitor silver and titanium nanoparticles in skin and to investigate the immune response they trigger.
Assessing Bioavailability of Monoclonal Antibodies
Detailed spatial- and time-resolved pharmacokinetic data obtained via aOFM enhance bioavailability prediction of subcutaneously delivered monoclonal antibodies (mAbs).
