Open Flow Microperfusion

OFM is a minimally-invasive interface to peripheral tissues for continuous sampling of interstitial fluid in pharmacokinetic and pharmacodynamic studies.

Products

Different OFM products are specifically designed to optimize sampling in various tissues.

Adipose Tissue

Adipose OFM (aOFM) assesses transport routes, drug dispersion, and drug effects in adipose tissue for e.g., insulins, GLP-1 receptor agonists.

Brain Tissue

Cerebral OFM (cOFM) monitors blood-brain-barrier (BBB) function and drug transport across the intact BBB for e. g., nanoformulations, antibodies.

Skin Tissue

Dermal OFM (dOFM) measures PK/PD of drugs in the dermis after topical or systemic application. e.g. antibodies, protein-bound drugs.

DISTRIBUTORS

Our preclinical OFM product line is available in the following regions through our distributors and JOANNEUM RESEARCH HEALTH:

Australia, China, Central America, Hong Kong, India, Israel, Japan, North America, Russia, Singapur, South America, South Korea

France, Switzerland

All other regions

OFM working principle

Technology

OFM is a membrane-free, time-resolved, minimally-invasive, in-vivo sampling technology developed by JOANNEUM RESEARCH.

OFM uses probes with macroscopic openings to exchange substances in a liquid pathway, that is based on concection and diffusion, so that the exchange can occur non-selectively in either direction.

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Project Partners

Your benefits

Universal

OFM samples all substances from the interstitial fluid independent of size, lipophilicity or protein-binding.

Targeted

OFM probes enable continuous sampling from clearly specified tissue types.

Cost and time efficient

OFM studies reduce costs and time by providing a complete pharmacological profile early in drug development.

Medical Device Regulation

Open Flow Microperfusion (OFM) is a CE-marked medical device technology for the minimally-invasive collection of analytes from the interstitial fluid of defined tissues. The OFM system enables continuous sampling in dermal tissue and subcutaneous adipose tissue in adult subjects within approved clinical studies. 

Any additional research applications described on this website refer to the OFM methodology and are not part of the intended use of the CE-marked medical device. Applications outside the intended use require separate regulatory evaluation and approval.