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Mag. Dr. Christoph Magnes

Role

Head of research group

Research group

HEALTH:

Bioanalytik und Metabolomics

Phone number

+43 316 876-4201

E-mail

Christoph.Magnes@joanneum.at

Adress

Neue Stiftingtalstraße 2, 8010, Graz
+43 316 876-4000
health@joanneum.at

Publications

Health
2024

Implementation and validation of a UHPLC-MS/MS method for quantification of the endocannabinoids AEA and 2-AG in cerebral interstitial fluid and plasma

Authors Weiermeier T, Svehlikova E, Magnes C, Boulgaropoulos B, Altendorfer-Kroath T, Hummer J, Eberl A
Implementation and validation of a UHPLC-MS/MS method for quantification of the endocannabinoids AEA and 2-AG in cerebral interstitial fluid and plasma
Health
2024

Enzymatic detection of α-hydroxybutyrate, an important marker of insulin resistance, and comparison with LC-MS/MS detection

Authors Steiner B, Leitner C, Stadler D, Prugger E, Magnes C, Herzog P
Enzymatic detection of α-hydroxybutyrate, an important marker of insulin resistance, and comparison with LC-MS/MS detection
Health
2023

Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models

Authors Costa-Machado, Luis Filipe; Garcia-Dominguez, Esther; McIntyre, Rebecca L; Lopez-Aceituno, Jose Luis; Ballesteros-Gonzalez, Álvaro; Tapia-Gonzalez, Andrea; Fabregat-Safont, David; Eisenberg, Tobias; Gomez, Jesús; Plaza, Adrian; Sierra-Ramirez, Aranzazu; Perez, Manuel; Villanueva-Bermejo, David; Fornari, Tiziana; Loza, María Isabel; Herradon, Gonzalo; Hofer, Sebastian J; Magnes, Christoph; Madeo, Frank; Duerr, Janet S; Pozo, Oscar J; Galindo, Maximo-Ibo; del Pino, Isabel; Houtkooper, Riekelt H; Megias, Diego; Viña, Jose; Gomez-Cabrera, Mari Carmen; Fernandez-Marcos, Pablo J
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Health
2023

H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase

Authors Ravindran Menon, Dinoop; Hammerlindl, Heinz; Gimenez, Gregory; Hammerlindl, Sabrina; Zuegner, Elmar; Torrano, Joachim; Bordag, Natalie; Emran, Abdullah Al; Giam, Maybelline; Denil, Simon; Pavelka, Norman; Tan, Aik-Choon; Sturm, Richard A.; Haass, Nikolas K.; Rancati, Giulia; Herlyn, Meenhard; Magnes, Christoph; Eccles, Michael R.; Fujita, Mayumi; Schaider, Helmut
H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase
Health
2023

Metabolic support by macrophages sustains colonic epithelial homeostasis

Authors Fritsch S, Sukhbaatar N, Gonzales K, Sahu A, Tran L, Vogel A, Mazic M, Wilson J, Forisch S, Mayr H, Oberle R, Weiszmann J, Brenner M, Vanhoutte R, Hofmann M, Pirnes-Karhu S, Magnes C, Kühnast T, Weckwerth W, Bock C, Klavins K, Hengstschläger M, MOissl-Eichinger C, Schabbauer G, Egger G, Pirinen E, Verhelst S, Weichhart T
Metabolic support by macrophages sustains colonic epithelial homeostasis
Health
2022

Alterations in the Kynurenine–Tryptophan Pathway and Lipid Dysregulation Are Preserved Features of COVID-19 in Hemodialysis

Authors Schuller, Max; Oberhuber, Monika; Prietl, Barbara; Zügner, Elmar; Prugger, Eva-maria; Magnes, Christoph; Kirsch, Alexander H; Schmaldienst, Sabine; Pieber, Thomas; Brodmann, Marianne; Rosenkranz, Alexander R; Eller, Philipp; Eller, Kathrin
Alterations in the Kynurenine–Tryptophan Pathway and Lipid Dysregulation Are Preserved Features of COVID-19 in Hemodialysis
Health
2022

Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism

Authors Zügner, Elmar; Yang, Hsiu-Chiung; Kotzbeck, Petra; Boulgaropoulos, Beate; Sourij, Harald; Hagvall, Sepideh; Elmore, Charles S.; Esterline, Russell; Moosmang, Sven; Oscarsson, Jan; Pieber, Thomas R.; Peng, Xiao-Rong; Magnes, Christoph
Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism
Health
2022

Effect of Liraglutide Treatment on Whole-body Glucose Fluxes in C-peptide–Positive Type 1 Diabetes During Hypoglycemia

Authors Zenz, Sabine; Regittnig, Werner1; Boulgaropoulos, Beate; Augustin, Thomas; Brunner, Martina; Korsatko, Stefan; Münzker, Julia; Narath, Sophie H.; Raml, Reingard; Magnes, Christoph; Pieber, Thomas R
Effect of Liraglutide Treatment on Whole-body Glucose Fluxes in C-peptide–Positive Type 1 Diabetes During Hypoglycemia
Coremed, Health
2022

Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism

Authors Zügner E; Yang HC; Kotzbeck P ; Boulgaropoulos B; Sourij H; Hagvall S; Elmore CS; Esterline R; Moosmang S; Oscarsson J; Pieber TR; Peng XR; Magnes C
Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism
Coremed, Health
2022

The effect of spermidine on autoimmunity and beta cell function in NOD mice

Authors Karacay C; Prietl B; Harer C; Ehall B; Haudum CW; Bounab K; Franz J; Eisenberg T; Madeo F; Kolb D; Hingerl K; Hausl M; Magnes C; Mautner SI; Kotzbeck P ; Pieber TR
The effect of spermidine on autoimmunity and beta cell function in NOD mice
Health
2022

Insights into the Composition of a Co-Culture of 10 Probiotic Strains (OMNi BiOTiC® AAD10) and Effects of Its Postbiotic Culture Supernatant

Authors Kienesberger, Bernhard; Obermüller, Beate; Singer, Georg; Arneitz, Christoph; Gasparella, Paolo; Klymiuk, Ingeborg; Horvath, Angela; Stadlbauer, Vanessa; Magnes, Christoph; Zügner, Elmar; López-García, Pablo; Trajanoski, Slave; Miekisch, Wolfram; Fuchs, Patricia; Till, Holger; Castellani, Christoph
Insights into the Composition of a Co-Culture of 10 Probiotic Strains (OMNi BiOTiC® AAD10) and Effects of Its Postbiotic Culture Supernatant
Health
2022

Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline

Authors Schwarz, Claudia; Benson, Gloria S.; Horn, Nora; Wurdack, Katharina; Grittner, Ulrike; Schilling, Ralph; Märschenz, Stefanie; Köbe, Theresa; Hofer, Sebastian J.; Magnes, Christoph; Stekovic, Slaven; Eisenberg, Tobias; Sigrist, Stephan J.; Schmitz, Dietmar; Wirth, Miranka; Madeo, Frank; Flöel, Agnes
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline
Health
2022

Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions

Authors Paulus, Michael G.; Renner, Kathrin; Nickel, Alexander G.; Brochhausen, Christoph; Limm, Katharina; Zügner, Elmar; Baier, Maria J.; Pabel, Steffen; Wallner, Stefan; Birner, Christoph; Luchner, Andreas; Magnes, Christoph; Oefner, Peter J.; Stark, Klaus J.; Wagner, Stefan; Maack, Christoph; Maier, Lars S.; Streckfuss-Bömeke, Katrin; Sossalla, Samuel; Dietl, Alexander
Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions
Coremed +
2021

A novel human ex vivo skin model to study early local responses to burn injuries

Authors Hofmann, Elisabeth; Fink, Julia; Eberl, Anita; Prugger, Eva-Maria; Kolb, Dagmar; Luze, Hanna; Schwingenschuh, Simon; Birngruber, Thomas; Magnes, Christoph; Mautner, Selma I; Kamolz, Lars-Peter; Kotzbeck, Petra
A novel human ex vivo skin model to study early local responses to burn injuries
Health
2021

Dietary spermidine improves cognitive function

Authors Schroeder, Sabrina; Hofer, Sebastian J.; Zimmermann, Andreas; Pechlaner, Raimund; Dammbrueck, Christopher; Pendl, Tobias; Marcello, G. Mark; Pogatschnigg, Viktoria; Bergmann, Martina; Müller, Melanie; Gschiel, Verena; Ristic, Selena; Tadic, Jelena; Iwata, Keiko; Richter, Gesa; Farzi, Aitak; Üçal, Muammer; Schäfer, Ute; Poglitsch, Michael; Royer, Philipp; Mekis, Ronald; Agreiter, Marlene; Tölle, Regine C.; Sótonyi, Péter; Willeit, Johann; Mairhofer, Barbara; Niederkofler, Helga; Pallhuber, Irmgard; Rungger, Gregorio; Tilg, Herbert; Defrancesco, Michaela; Marksteiner, Josef; Sinner, Frank; Magnes, Christoph; Pieber, Thomas R.; Holzer, Peter; Kroemer, Guido; Carmona-Gutierrez, Didac; Scorrano, Luca; Dengjel, Jörn; Madl, Tobias; Sedej, Simon; Sigrist, Stephan J.; Rácz, Bence; Kiechl, Stefan; Eisenberg, Tobias; Madeo, Frank
Dietary spermidine improves cognitive function
Health
2021

Metabolic profiling of attached and detached metformin and 2-deoxy-D-glucose treated breast cancer cells

Authors Repas, Jernej; Zügner, Elmar; Gole, Boris; Bizjak, Marusa; Ptocnik, Uros; Magnes, Christoph; Pavlin, Mojca
Metabolic profiling of attached and detached metformin and 2-deoxy-D-glucose treated breast cancer cells
Health
2020

Pharmacokinetics and Pharmacodynamics of Three Different Formulations of Insulin Aspart: A Randomized, Double-blind, Crossover Study in Men With Type 1 Diabetes

Authors Svehlikova, Eva; Mursic, Ines; Augustin, Thomas; Magnes, Christoph; Gerring, David; Jezek, Jan; Schwarzenbacher, Daniela; Ratzer, Maria; Wolf, Michael; Howell, Sarah; Zakrzewski, Leon; Urschitz, Martina; Tschapeller, Bernd; Gatschelhofer, Christina; Feichtner, Franz; Lawrence, Fiona; Pieber, Thomas R.
Pharmacokinetics and Pharmacodynamics of Three Different Formulations of Insulin Aspart: A Randomized, Double-blind, Crossover Study in Men With Type 1 Diabetes
Health
2020

Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung

Authors Ahrendt, Nancy; Steingrüber, Tobias; Rajces, Alexandra; Lopez-Rodriguez, Elena; Eisenberg, Tobias; Magnes, Christoph; Madeo, Frank; Sedej, Simon; Schmiedl, Andreas; Ochs, Matthias; Mühlfeld, Christian; Schipke, Julia
Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung
Health
2020

Feasibility of rapidly assessing reactive impurities mediated excipient incompatibility using a new method: A case study of famotidine-PEG system

Authors Saraf, Isha; Modhave, Dattatray; Kushwah, Varun; Neshchadin, Dmytro; Gescheidt, Georg; Trausinger, Gert; Melchior, Philipp; Magnes, Christoph; Paudel, Amrit
Feasibility of rapidly assessing reactive impurities mediated excipient incompatibility using a new method: A case study of famotidine-PEG system
Health
2019

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Authors Carmona-Gutierrez, Didac; Zimmermann, Andreas; Kainz, Katharina; Pietrocola, Federico; Chen, Guo; Maglioni, Silvia; Schiavi, Alfonso; Nah, Jihoon; Mertel, Sara; Beuschel, Christine B.; Castoldi, Francesca; Sica, Valentina; Trausinger, Gert; Raml, Reingard; Sommer, Cornelia; Schroeder, Sabrina; Hofer, Sebastian J.; Bauer, Maria A.; Pendl, Tobias; Tadic, Jelena; Dammbrueck, Christopher; Hu, Zehan; Ruckenstuhl, Christoph; Eisenberg, Tobias; Durand, Sylvere; Bossut, Noélie; Aprahamian, Fanny; Abdellatif, Mahmoud; Sedej, Simon; Enot, David P.; Wolinski, Heimo; Dengjel, Jörn; Kepp, Oliver; Magnes, Christoph; Sinner, Frank M.; Pieber, Thomas R.; Sadoshima, Junichi; Ventura, Natascia; Sigrist, Stephan J.; Kroemer, Guido; Madeo, Frank
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
Health
2019

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

Authors Stekovic, Slaven; Hofer, Sebastian J.; Tripolt, Norbert; Aon, Miguel A.; Royer, Philipp; Pein, Lukas; Stadler, Julia T.; Pendl, Tobias; Prietl, Barbara; Url, Jasmin; Schroeder, Sabrina; Tadic, Jelena; Eisenberg, Tobias; Magnes, Christoph; Stumpe, Michael; Zuegner, Elmar; Bordag, Natalie; Riedl, Regina; Schmidt, Albrecht; Kolesnik, Ewald; Verheyen, Nicolas; Springer, Anna; Madl, Tobias; Sinner, Frank; de Cabo, Rafael; Kroemer, Guido; Obermayer-Pietsch, Barbara; Dengjel, Jöm; Sourij, Harald; Pieber, Thomas R.; Madeo, Frank
Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans
Health
2019

N ‐acetylaspartate availability is essential for juvenile survival on fat‐free diet and determines metabolic health

Authors Hofer, Dina C.; Zirkovits, Gabriel; Pelzmann, Helmut J.; Huber, Katharina; Pessentheiner, Ariane R.; Xia, Wenmin; Uno, Kyosuke; Miyazaki, Toh; Kon, Kanta; Tsuneki, Hiroshi; Pendl, Tobias; Zoughbi, Wael Al; Madreiter‐Sokolowski, Corina T.; Trausinger, Gert; Abdellatif, Mahmoud; Schoiswohl, Gabriele; Schreiber, Renate; Eisenberg, Tobias; Magnes, Christoph; Sedej, Simon; Eckhardt, Matthias; Sasahara, Masakiyo; Sasaoka, Toshiyasu; Nitta, Atsumi; Hoefler, Gerald; Graier, Wolfgang F.; Kratky, Dagmar; Auwerx, Johan; Bogner‐Strauss, Juliane G.
N ‐acetylaspartate availability is essential for juvenile survival on fat‐free diet and determines metabolic health
Health
2019

Targeting the H3K4 demethylase KDM5B reprograms the metabolome and phenotype of melanoma cells

Authors Vogel, Felix C.E.; Bordag, Natalie; Zügner, Elmar; Trajkovic-Arsic, Marija; Chauvistré, Heike; Shannan, Batool; Váraljai, Renáta; Horn, Susanne; Magnes, Christoph; Siveke, Jens; Schadendorf, Dirk; Roesch, Alexander
Targeting the H3K4 demethylase KDM5B reprograms the metabolome and phenotype of melanoma cells
Health
2019

N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes

Authors Huber, Katharina; Hofer, Dina C; Trefely, Sophie; Pelzmann, Helmut J.; Madreiter-Sokolowski, Corina; Duta-Mare, Madalina; Schlager, Stefanie; Trausinger, Gert; Stryeck, Sarah; Graier, Wolfgang F.; Kolb, Dagmar; Magnes, Christoph; Snyder, Nathaniel W.; Prokesch, Andreas; Kratky, Dagmar; Madl, Tobias; Wellen, Kathryn E.; Bogner-Strauss, Juliane G.
N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes
Health
2018

Impact of C-Peptide Status on the Response of Glucagon and Endogenous Glucose Production to Induced Hypoglycaemia in T1D.

Authors Zenz, Sabine; Mader, Julia K; Regittnig, Werner; Brunner, Martina; Korsatko, Stefan; Boulgaropoulos, Beate; Magnes, Christoph; Raml, Reingard; Narath, Sophie H.; Eller, Philipp; Augustin, Thomas; Pieber, Thomas R
Impact of C-Peptide Status on the Response of Glucagon and Endogenous Glucose Production to Induced Hypoglycaemia in T1D.
Health
2018

Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis

Authors Duta-Mare, Madalina; Sachdev, Vinay; Leopold, Christina; Kolb, Dagmar; Vujic, Nemanja; Korbelius, Melanie; Hofer, Dina C; Xia, Wenmin; Huber, Katharina; Auer, Martina; Gottschalk, Benjamin; Magnes, Christoph; Graier, Wolfgang F.; Prokesch, Andreas; Radovic, Branislav; Bogner-Strauss, Juliane G.; Kratky, Dagmar
Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis
Health
2018

Progesterone-associated arginine decline at luteal phase of menstrual cycle and associations with related amino acids and nuclear factor kB activation

Authors Faustmann, Gernot; Meinitzer, Andreas; Magnes, Christoph; Tiran, Beate; Obermayer-Pietsch, Barbara; Gruber, Hans-Jürgen; Ribalta, Josep; Rock, Edmond; Roob, Johannes M.; Winklhofer-Roob, Brigitte M.
Progesterone-associated arginine decline at luteal phase of menstrual cycle and associations with related amino acids and nuclear factor kB activation
Health
2018

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline

Authors Schwarz, Claudia; Stekovic, Slaven; Wirth, Miranka; Benson, Gloria; Royer, Philipp; Sigrist, Stephan J; Pieber, Thomas R; Dammbrueck, Christopher; Magnes, Christoph; Eisenberg, Tobias; Pendl, Tobias; Bohlken, Jens; Köe, Theresa; Madeo, Frank; Flöel, Agnes
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline
Health
2016

An Untargeted Metabolomics Approach to Characterize Short-Term and Long-Term Metabolic Changes after Bariatric Surgery

Authors Narath, Sophie H.; Mautner, Selma I.; Svehlikova, Eva; Schultes, Bernd; Pieber, Thomas R.; Sinner, Frank M.; Gander, Edgar; Libiseller, Gunnar; Schimek, Michael G.; Sourij, Harald; Magnes, Christoph
An Untargeted Metabolomics Approach to Characterize Short-Term and Long-Term Metabolic Changes after Bariatric Surgery
Health
2016

Matrix removal in state of the art sample preparation methods for serum by charged aerosol detection and metabolomics-based LC-MS

Authors Schimek, Denise; Francesconi, Kevin A.; Mautner, Anton; Libiseller, Gunnar; Raml, Reingard; Magnes, Christoph
Matrix removal in state of the art sample preparation methods for serum by charged aerosol detection and metabolomics-based LC-MS
Health
2016

Determination of (2)H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography - quadrupole-mass-spectrometry

Authors Eberl, A; Altendorfer‐Kroath, Thomas; Kollmann, D; Birngruber, Thomas; Sinner, F; Raml, R; Magnes, Christoph
Determination of (2)H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography - quadrupole-mass-spectrometry
Health
2016

N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes.

Authors Prokesch, Andreas; Pelzmann, H J; Pessentheiner, A R; Huber, K; Madreiter-Sokolowski, C T; Drougard, A; Schittmayer, M; Kolb, D; Magnes, Christoph; Trausinger, Gert; Graier, W F; Birner-Gruenberger, R; Pospisilik, J A; Bogner-Strauss, J G
N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes.
Health
2016

Cardioprotection and lifespan extension by the natural polyamine spermidine

Authors Eisenberg, Tobias; Abdellatif, Mahmoud; Schroeder, Sabrina; Primessnig, Uwe; Stekovic, Slaven; Pendl, Tobias; Harger, Alexandra; Schipke, Julia; Zimmermann, Andreas; Schmidt, Albrecht; Tong, Mingming; Ruckenstuhl, Christoph; Dammbrueck, Christopher; Gross, Angelina S; Herbst, Viktoria; Magnes, Christoph; Trausinger, Gert; Narath, Sophie; Meinitzer, Andreas; Hu, Zehan; Kirsch, Alexander; Eller, Kathrin; Carmona-Gutierrez, Didac; Büttner, Sabrina; Pietrocola, Federico; Knittelfelder, Oskar; Schrepfer, Emilie; Rockenfeller, Patrick; Simonini, Corinna; Rahn, Alexandros; Horsch, Marion; Moreth, Kristin; Beckers, Johannes; Fuchs, Helmut; Gailus-Durner, Valerie; Neff, Frauke; Janik, Dirk; Rathkolb, Birgit; Rozman, Jan; de Angelis, Martin Hrabe; Moustafa, Tarek; Haemmerle, Guenter; Mayr, Manuel; Willeit, Peter; von Frieling-Salewsky, Marion; Pieske, Burkert; Scorrano, Luca; Pieber, Thomas R; Pechlaner, Raimund; Willeit, Johann; Sigrist, Stephan J; Linke, Wolfgang A; Mühlfeld, Christian; Sadoshima, Junichi; Dengjel, Joern; Kiechl, Stefan; Kroemer, Guido; Sedej, Simon; Madeo, Frank
Cardioprotection and lifespan extension by the natural polyamine spermidine
Health
2016

Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication

Authors Fröhlich, Esther E.; Farzi, Aitak; Mayerhofer, Raphaela; Reichmann, Florian; Jačan, Angela; Wagner, Bernhard; Zinser, Erwin; Bordag, Natalie; Magnes, Christoph; Fröhlich, Eleonore Esther E.; Kashofer, Karl; Gorkiewicz, Gregor; Holzer, Peter
Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication
Health
2015

IPO: a tool for automated optimization of XCMS parameters

Authors Libiseller, Gunnar; Dvorzak, Michaela; Kleb, Ulrike; Gander, Edgar; Eisenberg, Tobias; Madeo, Frank; Neumann, Steffen; Trausinger, Gert; Sinner, Frank; Pieber, Thomas; Magnes, Christoph
IPO: a tool for automated optimization of XCMS parameters
Health
2015

Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin

Authors Braun, Ralf J.; Sommer, Cornelia; Leibiger, Christine; Gentier, Romina J.G.; Dumit, Verónica I.; Paduch, Katrin; Eisenberg, Tobias; Habernig, Lukas; Trausinger, Gert; Magnes, Christoph; Pieber, Thomas; Sinner, Frank; Dengjel, Jörn; van Leeuwen, Fred W.; Kroemer, Guido; Madeo, Frank
Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin
Health
2015

Identification of novel metabolic interactions controlling carbon flux from xylose to ethanol in natural and recombinant yeasts

Authors Trausinger, Gert; Gruber, Christoph; Krahulec, Stefan; Magnes, Christoph; Nidetzky, Bernd; Klimacek, Mario
Identification of novel metabolic interactions controlling carbon flux from xylose to ethanol in natural and recombinant yeasts
Health
2015

Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast

Authors Braun, Ralf J.; Sommer, Cornelia; Leibiger, Christine; Gentier, Romina; Dumit, Veronica; Paduch, Katrin; Eisenberg, Tobias; Habernig, Lukas; Trausinger, Gert; Magnes, Christoph; Pieber, Thomas R; Sinner, Frank M; Dengjel, Jörn; van Leeuwen, Fred; Kroemer, Guido; Madeo, Frank
Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast
Health
2013

Spermidine promotes mating and fertilization efficiency in model organisms

Authors Bauer, Maria Anna; Carmona-Gutiérrez, Didac; Ruckenstuhl, Christoph; Reisenbichler, Angela; Megalou, Evgenia V.; Eisenberg, Tobias; Magnes, Christoph; Jungwirth, Helmut; Sinner, Frank M; Pieber, Thomas R; Fröhlich, Kai Uwe; Kroemer, Guido; Tavernarakis, Nektarios; Madeo, Frank
Spermidine promotes mating and fertilization efficiency in model organisms
Health
2012

Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling

Authors Bodenlenz, Manfred; Höfferer, Christian; Magnes, Christoph; Schaller-Ammann, Roland; Schaupp, Lukas; Feichtner, Franz; Ratzer, Maria; Pickl, Karin; Sinner, Frank; Wutte, Andrea; Korsatko, Stefan; Köhler, Gerd; Legat, Franz J.; Benfeldt, Eva M.; Wright, Andrew M.; Neddermann, Daniel; Jung, Thomas; Pieber, Thomas R
Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling
Health
2012

Remodeling of lipid droplets during lipolysis and growth in adipocytes

Authors Paar, Margret; Jüngst, Christian; Steiner, Noemi A.; Magnes, Christoph; Sinner, Frank; Kolb, Dagmar; Lass, Achim; Zimmermann, Robert; Zumbusch, Andreas; Kohlwein, Sepp D.; Wolinski, Heimo
Remodeling of lipid droplets during lipolysis and growth in adipocytes
Health
2012

Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury

Authors Moustafa, Tarek; Fickert, Peter; Magnes, Christoph; Guelly, Christian; Thueringer, Andrea; Frank, Sasa; Kratky, Dagmar; Sattler, Wolfgang; Reicher, Helga; Sinner, Frank; Gumhold, Judith; Silbert, Dagmar; Fauler, Günter; Höfler, Gerald; Lass, Achim; Zechner, Rudolf; Trauner, Michael
Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury
Health
2011

Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats

Authors Ardjomand-Woelkart, Karin; Kollroser, Manfred; Magnes, Christoph; Sinner, Frank; Frye, Reginald F; Derendorf, Hartmut; Bauer, Rudolf; Butterweck, Veronika
Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats
Health
2011

The propeptide of yeast cathepsin D inhibits programmed necrosis

Authors Carmona-Gutiérrez, D; Bauer, M A; Ring, J; Knauer, H; Eisenberg, T; Büttner, S; Ruckenstuhl, C; Reisenbichler, A; Magnes, C; Rechberger, G N; Birner-Gruenberger, R; Jungwirth, H; Fröhlich, K-U; Sinner, F; Kroemer, G; Madeo, F
The propeptide of yeast cathepsin D inhibits programmed necrosis
Health
2010

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase

Authors Chandak, Prakash G.; Radović, Branislav; Aflaki, Elma; Kolb, Dagmar; Buchebner, Marlene; Fröhlich, Eleonore; Magnes, Christoph; Sinner, Frank; Haemmerle, Guenter; Zechner, Rudolf; Tabas, Ira; Levak-Frank, Sanja; Kratky, Dagmar
Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase
Health
2009

Induction of autophagy by spermidine promotes longevity

Authors Eisenberg, Tobias; Knauer, Heide; Schauer, Alexandra; Büttner, Sabrina; Ruckenstuhl, Christoph; Carmona-Gutierrez, Didac; Ring, Julia; Schroeder, Sabrina; Magnes, Christoph; Antonacci, Lucia; Fussi, Heike; Deszcz, Luiza; Hartl, Regina; Schraml, Elisabeth; Criollo, Alfredo; Megalou, Evgenia; Weiskopf, Daniela; Laun, Peter; Heeren, Gino; Breitenbach, Michael; Grubeck-Loebenstein, Beatrix; Herker, Eva; Fahrenkrog, Birthe; Fröhlich, Kai-Uwe; Sinner, Frank; Tavernarakis, Nektarios; Minois, Nadege; Kroemer, Guido; Madeo, Frank
Induction of autophagy by spermidine promotes longevity
Health
2008

Insulin glulisine, insulin lispro and regular human insulin show comparable end-organ metabolic effects: an exploratory study

Authors Horvath, K; Bock, G; Regittnig, W; Bodenlenz, Manfred; Wutte, A; Plank, J; Magnes, Christoph; Sinner, F.; Fürst-Recktenwald, S.; Theobald, K; Pieber, Thomas R
Insulin glulisine, insulin lispro and regular human insulin show comparable end-organ metabolic effects: an exploratory study
Health
2008

Ring-opening metathesis polymerization-derived monolithic capillary columns for high-performance liquid chromatography. Downscaling and application in medical research

Authors Sinner, Frank M; Gatschelhofer, Christina; Mautner, Agnes; Magnes, Christoph; Buchmeiser, Michael R; Pieber, Thomas R
Ring-opening metathesis polymerization-derived monolithic capillary columns for high-performance liquid chromatography. Downscaling and application in medical research
Health
2008

Validated comprehensive analytical method for quantification of coenzyme A activated compounds in biological tissues by online solid-phase extraction LC/MS/MS.

Authors Magnes, Christoph; Suppan, Maria; Pieber, Thomas R; Moustafa, Tarek; Trauner, Michael; Haemmerle, Guenter; Sinner, Frank M
Validated comprehensive analytical method for quantification of coenzyme A activated compounds in biological tissues by online solid-phase extraction LC/MS/MS.
Health
2007

Proportional Dose-Response Relationship and Lower Within-Patient Variability of Insulin Detemir and NPH Insulin in Subjects With Type 1 Diabetes Mellitus

Authors Wutte, A; Plank, J; Bodenlenz, Manfred; Magnes, Christoph; Regittnig, W; Sinner, F.; Rønn, B.; Zdravkovic, M; Pieber, T.
Proportional Dose-Response Relationship and Lower Within-Patient Variability of Insulin Detemir and NPH Insulin in Subjects With Type 1 Diabetes Mellitus
Health
2007

Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion

Authors Pickl, Karin E.; Magnes, Christoph; Bodenlenz, Manfred; Pieber, Thomas R.; Sinner, Frank M.
Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion
Health
2005

A Double-Blind, Randomized, Dose-Response Study Investigating the Pharmacodynamic and Pharmacokinetic Properties of the Long-Acting Insulin Analog Detemir

Authors Plank, Johannes; Bodenlenz, Manfred; Sinner, Frank; Magnes, Christoph; Görzer, Evelyn; Regittnig, Werner; Endahl, Lars A.; Draeger, Eberhard; Zdravkovic, Milan; Pieber, Thomas R
A Double-Blind, Randomized, Dose-Response Study Investigating the Pharmacodynamic and Pharmacokinetic Properties of the Long-Acting Insulin Analog Detemir
Health
2005

LC/MS/MS Method for Quantitative Determination of Long-Chain Fatty Acyl-CoAs

Authors Magnes, Christoph; Sinner, Frank M; Regittnig, Werner; Pieber, Thomas R
LC/MS/MS Method for Quantitative Determination of Long-Chain Fatty Acyl-CoAs
Health
2005

Evaluation of ring-opening metathesis polymerization (ROMP)-derived monolithic capillary high performance liquid chromatography columns

Authors Gatschelhofer, Christina; Magnes, Christoph; Pieber, Thomas R; Buchmeiser, Michael R; Sinner, Frank M
Evaluation of ring-opening metathesis polymerization (ROMP)-derived monolithic capillary high performance liquid chromatography columns
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