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Dr.in Reingard Raml

Role

Deputy head of research group

Research group

HEALTH:

Bioanalysis and Metabolomics

Phone number

+43 316 876-4212

E-mail

Reingard.Raml@joanneum.at

Address

Neue Stiftingtalstraße 2, 8010, Graz
+43 316 876-4000
health@joanneum.at

Publications

Health
2025

Open flow microperfusion to assess local drug concentrations in the buccal mucosa

Authors Laura Wiltschko, Paula Fischer, Simon Schwingenschuh, Reingard Raml, Georg Raber, Thomas Birngruber, Eva Roblegg
Open flow microperfusion to assess local drug concentrations in the buccal mucosa
Health
2025

Impact of protein binding on drug sampling by microdialysis and open flow microperfusion

Authors Laura Wiltschko, Simon Schwingenschuh, Peter Reisenegger, Stephanie Eder, Manfred Bodenlenz, Eva Roblegg, Thomas Birngruber, Reingard Raml
Impact of protein binding on drug sampling by microdialysis and open flow microperfusion
Health
2025

Inkjet-printed drug-loaded temporary tattoos for personalized pediatric pain treatment

Authors Eder, Simone and Wolfgang, Matthias and Zettl, Manuel and Wiltschko, Laura and Raml, Reingard and Roblegg, Eva and Spoerk, Martin
Inkjet-printed drug-loaded temporary tattoos for personalized pediatric pain treatment
Health
2024

Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model

Authors Bodenlenz M, Yeaho T, Berstein G, Mathew S, Shah J, Banfield C, Hollingshead B, Steyn S, Osgood S, Beaumont K, Kainz S, Holecek C, Trausinger G, Raml R, Birngruber T
Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model
Health
2024

Cutaneous pharmacokinetics-based bioequivalence: A clinical dermal open flow microperfusion verification study using lidocaine and prilocaine combination topical products

Authors Tiffner, K. I., Ramezanli, T., Boulgaropoulos, B., Birngruber, T., Bodenlenz, M., Lackner, B. C., Raml, R., Jiang, Y., Raney, S. G., & Sinner, F.
Cutaneous pharmacokinetics-based bioequivalence: A clinical dermal open flow microperfusion verification study using lidocaine and prilocaine combination topical products
Health
2023

Quantification of the Therapeutic Antibody Ocrelizumab in Mouse Brain Interstitial Fluid Using Cerebral Open Flow Microperfusion and Simultaneous Monitoring of the Blood–Brain Barrier Integrity

Authors Altendorfer-Kroath, Thomas; Hummer, Joanna; Kollmann, Denise; Boulgaropoulos, Beate; Raml, Reingard; Birngruber, Thomas
Quantification of the Therapeutic Antibody Ocrelizumab in Mouse Brain Interstitial Fluid Using Cerebral Open Flow Microperfusion and Simultaneous Monitoring of the Blood–Brain Barrier Integrity
Health
2023

Small volume rapid equilibrium dialysis (RED) measures effects of interstitial parameters on the protein-bound fraction of topical drugs

Authors Wiltschko, Laura; Roblegg, Eva; Raml, Reingard; Birngruber, Thomas
Small volume rapid equilibrium dialysis (RED) measures effects of interstitial parameters on the protein-bound fraction of topical drugs
Health
2022

Assessment of Two Different Glucagon Assays in Healthy Individuals and Type 1 and Type 2 Diabetes Patients

Authors Brunner, Martina; Moser, Othmar; Raml, Reingard; Haberlander, Maximilian; Boulgaropoulos, Beate; Obermayer-Pietsch, Barbara; Svehlikova, Eva; Pieber, Thomas R.; Sourij, Harald
Assessment of Two Different Glucagon Assays in Healthy Individuals and Type 1 and Type 2 Diabetes Patients
Health
2022

Effect of Liraglutide Treatment on Whole-body Glucose Fluxes in C-peptide–Positive Type 1 Diabetes During Hypoglycemia

Authors Zenz, Sabine; Regittnig, Werner1; Boulgaropoulos, Beate; Augustin, Thomas; Brunner, Martina; Korsatko, Stefan; Münzker, Julia; Narath, Sophie H.; Raml, Reingard; Magnes, Christoph; Pieber, Thomas R
Effect of Liraglutide Treatment on Whole-body Glucose Fluxes in C-peptide–Positive Type 1 Diabetes During Hypoglycemia
Health
2022

Chronic Inflammation Might Protect Hemodialysis Patients From Severe COVID-19

Authors Prietl, Barbara; Odler, Balazs; Kirsch, Alexander H.; Artinger, Katharina; Eigner, Manfred; Schmaldienst, Sabine; Pfeifer, Verena; Stanzer, Stefanie; Eberl, Anita; Raml, Reingard; Pieber, Thomas; Rosenkranz, Alexander R.; Brodmann, Marianne; Eller, Philipp; Eller, Kathrin
Chronic Inflammation Might Protect Hemodialysis Patients From Severe COVID-19
Health
2021

Comparative in vitro release testing (IVRT) of acyclovir products

Authors Katrin I. Tiffner, Isadore Kanfer, Thomas Augustin, Reingard Raml, Sam G. Raney, Frank Sinner
Comparative in vitro release testing (IVRT) of acyclovir products
Health
2020

OFM recirculation and OFM suction: Advanced in-vivo open flow microperfusion methods for direct and absolute quantification of albumin in interstitial fluid

Authors Hummer, Joanna; Schwingenschuh, Simon; Raml, Reingard; Boulgaropoulos, Beate; Schwagerle, Gerd; Augustin, Thomas; Sinner, Frank; Birngruber, Thomas
OFM recirculation and OFM suction: Advanced in-vivo open flow microperfusion methods for direct and absolute quantification of albumin in interstitial fluid
Health
2019

Comparison of cerebral Open Flow Microperfusion and Microdialysis when sampling small lipophilic and small hydrophilic substances

Authors Altendorfer-Kroath, Thomas; Schimek, Denise; Eberl, Anita; Rauter, Günther; Ratzer, Maria; Raml, Reingard; Sinner, Frank; Birngruber, Thomas
Comparison of cerebral Open Flow Microperfusion and Microdialysis when sampling small lipophilic and small hydrophilic substances
Health
2019

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Authors Carmona-Gutierrez, Didac; Zimmermann, Andreas; Kainz, Katharina; Pietrocola, Federico; Chen, Guo; Maglioni, Silvia; Schiavi, Alfonso; Nah, Jihoon; Mertel, Sara; Beuschel, Christine B.; Castoldi, Francesca; Sica, Valentina; Trausinger, Gert; Raml, Reingard; Sommer, Cornelia; Schroeder, Sabrina; Hofer, Sebastian J.; Bauer, Maria A.; Pendl, Tobias; Tadic, Jelena; Dammbrueck, Christopher; Hu, Zehan; Ruckenstuhl, Christoph; Eisenberg, Tobias; Durand, Sylvere; Bossut, Noélie; Aprahamian, Fanny; Abdellatif, Mahmoud; Sedej, Simon; Enot, David P.; Wolinski, Heimo; Dengjel, Jörn; Kepp, Oliver; Magnes, Christoph; Sinner, Frank M.; Pieber, Thomas R.; Sadoshima, Junichi; Ventura, Natascia; Sigrist, Stephan J.; Kroemer, Guido; Madeo, Frank
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
Health
2018

A comprehensive approach to qualify and validate the essential parameters of an in vitro release test (IVRT) method for acyclovir cream, 5%

Authors Tiffner, Katrin Irene; Kanfer, Isadore; Augustin, Thomas; Raml, Reingard; Raney, Sam G.; Sinner, Frank M.
A comprehensive approach to qualify and validate the essential parameters of an in vitro release test (IVRT) method for acyclovir cream, 5%
Health
2018

Impact of C-Peptide Status on the Response of Glucagon and Endogenous Glucose Production to Induced Hypoglycaemia in T1D.

Authors Zenz, Sabine; Mader, Julia K; Regittnig, Werner; Brunner, Martina; Korsatko, Stefan; Boulgaropoulos, Beate; Magnes, Christoph; Raml, Reingard; Narath, Sophie H.; Eller, Philipp; Augustin, Thomas; Pieber, Thomas R
Impact of C-Peptide Status on the Response of Glucagon and Endogenous Glucose Production to Induced Hypoglycaemia in T1D.
Health
2018

Quantification of acyclovir in dermal interstitial fluid and human serum by ultra-high-performance liquid-high-resolution tandem mass spectrometry for topical bioequivalence evaluation

Authors Schimek, Denise; Raml, Reingard; Francesconi, Kevin A.; Bodenlenz, Manfred; Sinner, Frank
Quantification of acyclovir in dermal interstitial fluid and human serum by ultra-high-performance liquid-high-resolution tandem mass spectrometry for topical bioequivalence evaluation
Health
2017

Assessment of skin permeability to topically applied drugs by skin impedance and admittance.

Authors Schwingenschuh, Simon; Scharfetter, Hermann; Martinsen, Orjan Grottem; Boulgaropoulos, Beate; Augustin, Thomas; Tiffner, Katrin Irene; Dragatin, Christian; Raml, Reingard; Hoefferer, Christian; Prandl, Eva-Christina; Sinner, Frank M.; Hajnsek, Martin
Assessment of skin permeability to topically applied drugs by skin impedance and admittance.
Health
2017

Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence

Authors Bodenlenz, Manfred; Tiffner, Katrin Irene; Raml, Reingard; Augustin, Thomas; Dragatin, Christian; Birngruber, Thomas; Schimek, Denise; Schwagerle, Gerd; Pieber, Thomas R.; Raney, Sam G.; Kanfer, Isadore; Sinner, Frank
Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence
Health
2016

Matrix removal in state of the art sample preparation methods for serum by charged aerosol detection and metabolomics-based LC-MS

Authors Schimek, Denise; Francesconi, Kevin A.; Mautner, Anton; Libiseller, Gunnar; Raml, Reingard; Magnes, Christoph
Matrix removal in state of the art sample preparation methods for serum by charged aerosol detection and metabolomics-based LC-MS
Health
2016

Kinetics of Clobetasol-17-Propionate in Psoriatic Lesional and Non-Lesional Skin Assessed by Dermal Open Flow Microperfusion with Time and Space Resolution

Authors Bodenlenz, Manfred; Dragatin, Christian; Liebenberger, Lisa; Tschapeller, Bernd; Boulgaropoulos, Beate; Augustin, Thomas; Raml, Reingard; Gatschelhofer, Christina; Wagner, Nathalie; Benkali, Khaled; Rony, Francois; Pieber, Thomas; Sinner, Frank
Kinetics of Clobetasol-17-Propionate in Psoriatic Lesional and Non-Lesional Skin Assessed by Dermal Open Flow Microperfusion with Time and Space Resolution
Health
2016

Determination of (2)H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography - quadrupole-mass-spectrometry

Authors Eberl, A; Altendorfer‐Kroath, Thomas; Kollmann, D; Birngruber, Thomas; Sinner, F; Raml, R; Magnes, Christoph
Determination of (2)H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography - quadrupole-mass-spectrometry
Health
2014

Enhanced Doxorubicin Delivery to the Brain Administered Through Glutathione PEGylated Liposomal Doxorubicin (2B3-101) as Compared with Generic Caelyx,®/Doxil®—A Cerebral Open Flow Microperfusion Pilot Study

Authors Birngruber, Thomas; Raml, Reingard; Gladdines, Werner; Gatschelhofer, Christina; Gander, Edgar; Ghosh, Arijit; Kroath, Thomas; Gaillard, Pieter J; Pieber, Thomas R; Sinner, Frank
Enhanced Doxorubicin Delivery to the Brain Administered Through Glutathione PEGylated Liposomal Doxorubicin (2B3-101) as Compared with Generic Caelyx,®/Doxil®—A Cerebral Open Flow Microperfusion Pilot Study
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JOANNEUM RESEARCH provides innovation and technology services in the field of applied research. As a research company working on behalf of various federal provinces and regions in Austria, our expertise shapes the development of our modern society and economy – sustainably, and always with a focus on people. As a multidisciplinary team working in a flexible set-up that fosters innovation, we always live up to the highest social and scientific standards.

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