Bioanalyses for pharacokinetic/phamacodynamic studies, metabolomics for clinical research and pharmaceutical analyses
We are experts in the development and validation of analytical methods according to GLP/GCP standards. The focus is on chromatographic mass spectrometric methods and immunoassays.
Bioanalysis:
Detection of biological or pharmaceutical substances in biological samples from clinical and preclinical studies: Our expertise lies in the detection of the lowest concentrations in the smallest sample volumes (µl).
Metabolomics:
Specific (targeted) and broad (untargeted) metabolomics analyses for the determination and quantification of metabolites from metabolic processes for biomarker research
Pharmaceutical Analysis:
Active ingredient analysis for quality assurance of pharmaceutical production facilities, for the validation of cleaning processes (batch release), content determination, testing for impurities in pharmaceutical products
Instrumentation:
HPLC-MS (high-resolution mass spectrometer)
UHPLC-Q-Exactive (Thermo Scientific®)
HPLC-LTQ Orbitrap XL (Thermo Scientific®)
HPLC-MS/MS (triple quadrupole mass spectrometer)
Agilent 6495 Triple Quad UHPLC-MS/MS
Thermo Scientific(R) TSQ Quantum UHPLC-MS/MS
Thermo Scientific(R) TSQ Quantum HPLC-MS/MS
GC-MS (triple quadrupole mass spectrometer)
GC-MS/MS: Agilent 7890A/7000B inkl CTC Pal Combi XT Autosampler
HPLC-UV
Agilent 1290 Infinity 2 , DAD detector
Thermo Scientific®, UHPLC Vanquishe, UV detector
Robotic Liquid Handling Workstation: Hamilton® Microlab STARlet liquid handling system