Instruments and methods for the measurement of pharmacokinetics and pharmacodynamics in different tissues.
Open Flow Microperfusion (OFM) - Technology
OFM enables the continuous collection of interstitial fluid in (pre)clinical studies for drug development and biomarker research.
OFM is a patented, probe-based and membrane-free method for the continuous collection of minute amounts of interstitial fluid from various tissues. It enables access to the entire biochemical information of the interstitium and thus opens up completely new perspectives in preclinical and clinical (pharmacological) research and drug testing. The membrane-free OFM probes have an exchange surface without a diffusion barrier, so that sampling is not restricted by the size, lipophilicity of substances or protein binding effects.
Applications:pharmacokinetics, pharmacodynamics, bioequivalence, bioavailability, dose finding, drug metabolism
Substances: active pharmaceutical ingredients (low molecular weight to antibody-drug conjugates; fat- or water-soluble), endogenous substances (substances ranging from small molecules to cells)
Preclinical models: pig, rat, mouse
Tissue:skin, mucous membrane, brain, muscle, fatty tissue, lymph, cancer
Preclinical Research
We manufacture OFM materials for preclinical studies and distribute them worldwide.
Products: information on the various OFM products, our product catalog, application videos, FAQs or the instructions for use can be found here
Sales regions and countries: Europe, North, Central and South America, Japan, China, South Korea, Hong Kong, Singapore, Australia, Russia, Israel, India. Write us and we will put you in touch with your local sales partner.
Clinical Research
OFM materials for clinical studies are approved as medical devices and CE certified.
Applications: skin, muscle, fatty tissue
Pharmacological Studies
In Vitro Release Tests (IVRT): testing the release of active ingredients from creams, ointments, and gels (semi-solid dosage formulations) with Franz diffusion cells Learn more
Ex-Vivo Tests: transdermal or transepidermal transport of active ingredients from creams, ointments and gels with human skin explants, artificial or cultured skin, with continuous or point measurement methods (open microperfusion, microdialysis, biopsies, tape stripping) Learn more
Preclinical Studies: preclinical in-vivo evaluation of PK/PD profiles in healthy and diseased animal models (mouse, rat, pig) in different tissues - skin, brain, adipose tissue, muscle, mucosa, lymph
Clinical Studies:clinical investigation of PK/PD profiles in healthy volunteers and patients directly in the target tissue - skin, adipose tissue
Bioanalysis: detection of biological or pharmaceutical substances in biological samples from clinical and preclinical studies
Metabolomics: Specific (targeted) and broad (untargeted) metabolomics analyses for the determination and quantification of metabolites from metabolic processes for biomarker research