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Priv.-Doz. DI Dr. Frank Sinner

Role

Vice President Regulatory and Strategic Affairs

Phone number

+43 316 876-4002

E-mail

Frank.Sinner@joanneum.at

Address

Neue Stiftingtalstraße 2, 8010, Graz
+43 316 876-4000
health@joanneum.at

Publications

Health
2024

Cutaneous pharmacokinetics-based bioequivalence: A clinical dermal open flow microperfusion verification study using lidocaine and prilocaine combination topical products

Authors Tiffner, K. I., Ramezanli, T., Boulgaropoulos, B., Birngruber, T., Bodenlenz, M., Lackner, B. C., Raml, R., Jiang, Y., Raney, S. G., & Sinner, F.
Cutaneous pharmacokinetics-based bioequivalence: A clinical dermal open flow microperfusion verification study using lidocaine and prilocaine combination topical products
Health
2024

Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopic Dermatitis

Authors Monedeiro, F., Ehall, B., Tiffner, K., Eberl, A., Svehlikova, E., Prietl, B., Pfeifer, V., Senekowitsch, J., Remm, A., Rebane, A., Magnes, C., Pieber, T., Sinner, F., & Birngruber, T.
Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopic Dermatitis
Health
2024

In Vitro and In Vivo Techniques to Assess Neurotoxicity of Nanoparticles

Authors Thomas Birngruber, James Okereke, Vadym Shapovalov, Eleonore Fröhlich, Frank Sinner, John S. Yu, Ming Hsieh, Babak Kateb, Thomas R. Pieber
In Vitro and In Vivo Techniques to Assess Neurotoxicity of Nanoparticles
Health
2022

Dermal open flow microperfusion for PK-based clinical bioequivalence studies of topical drug products

Authors Birngruber, Thomas; Tiffner, Katrin Irene; Mautner, Selma I; Sinner, Frank M.
Dermal open flow microperfusion for PK-based clinical bioequivalence studies of topical drug products
Health
2022

Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs

Authors Hummer, Joanna; Birngruber, Thomas; Sinner, Frank; Page, Leanne; Toner, Frank; Roper, Clive S.; Moore, David J.; Baker, Mark B.; Boncheva Bettex, Mila
Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs
Health
2022

Digital algorithm-guided insulin therapy in home healthcare for elderly persons with type 2 diabetes: A proof-of-concept study

Authors Kopanz, Julia; Mader, Julia K.; Donsa, Klaus; Libiseller, Angela; Aberer, Felix; Pandis, Marlene; Reinisch-Gratzer, Johanna; Ambrosch, Gisela C.; Lackner, Bettina; Truskaller, Thomas; Sinner, Frank Michael; Pieber, Thomas Rudolf; Lichtenegger, Katharina M.
Digital algorithm-guided insulin therapy in home healthcare for elderly persons with type 2 diabetes: A proof-of-concept study
Health
2021

Electronic Diabetes Management System Replaces Paper Insulin Chart: Improved Quality in Diabetes Inpatient Care Processes Due to Digitalization

Authors Kopanz, Julia; Lichtenegger, Katharina M.; Koenig, Constanze; Libiseller, Angela; Mader, Julia K.; Donsa, Klaus; Truskaller, Thomas; Bauer, Norbert; Hahn, Brigitte; Sendlhofer, Gerald; Beck, Peter; Höll, Bernhard; Sinner, Frank; Feichtner, Franz; Pieber, Thomas R.
Electronic Diabetes Management System Replaces Paper Insulin Chart: Improved Quality in Diabetes Inpatient Care Processes Due to Digitalization
Health
2021

Dermal sampling techniques with focus on dermal Open Flow Microperfusion

Authors Birngruber, Thomas; Boulgaropoulos, Beate; Sinner, Frank
Dermal sampling techniques with focus on dermal Open Flow Microperfusion
Health
2021

Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging

Authors Handler, Anne Mette; Eirefelt, Stefan; Lambert, Maja; Johansson, Fredrik; Hollesen Schefe, Line; Østergaard Knudsen, Nina; Bodenlenz, Manfred; Birngruber, Thomas; Sinner, Frank; Huss Erikson, André; Pommergaard Pedersen, Gitte; Janfelt, Christian; Troensegaard Nielsen, Kim
Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging
Health
2021

Dietary spermidine improves cognitive function

Authors Schroeder, Sabrina; Hofer, Sebastian J.; Zimmermann, Andreas; Pechlaner, Raimund; Dammbrueck, Christopher; Pendl, Tobias; Marcello, G. Mark; Pogatschnigg, Viktoria; Bergmann, Martina; Müller, Melanie; Gschiel, Verena; Ristic, Selena; Tadic, Jelena; Iwata, Keiko; Richter, Gesa; Farzi, Aitak; Üçal, Muammer; Schäfer, Ute; Poglitsch, Michael; Royer, Philipp; Mekis, Ronald; Agreiter, Marlene; Tölle, Regine C.; Sótonyi, Péter; Willeit, Johann; Mairhofer, Barbara; Niederkofler, Helga; Pallhuber, Irmgard; Rungger, Gregorio; Tilg, Herbert; Defrancesco, Michaela; Marksteiner, Josef; Sinner, Frank; Magnes, Christoph; Pieber, Thomas R.; Holzer, Peter; Kroemer, Guido; Carmona-Gutierrez, Didac; Scorrano, Luca; Dengjel, Jörn; Madl, Tobias; Sedej, Simon; Sigrist, Stephan J.; Rácz, Bence; Kiechl, Stefan; Eisenberg, Tobias; Madeo, Frank
Dietary spermidine improves cognitive function
Health
2021

Comparative in vitro release testing (IVRT) of acyclovir products

Authors Katrin I. Tiffner, Isadore Kanfer, Thomas Augustin, Reingard Raml, Sam G. Raney, Frank Sinner
Comparative in vitro release testing (IVRT) of acyclovir products
Health
2020

Variability of Skin Pharmacokinetic Data: Insights from a Topical Bioequivalence Study Using Dermal Open Flow Microperfusion

Authors Bodenlenz, Manfred; Augustin, Thomas; Birngruber, Thomas; Tiffner, Katrin Irene; Boulgaropoulos, Beate; Schwingenschuh, Simon; Raney, Sam G.; Rantou, Elena; Sinner, Frank
Variability of Skin Pharmacokinetic Data: Insights from a Topical Bioequivalence Study Using Dermal Open Flow Microperfusion
Health
2020

OFM recirculation and OFM suction: Advanced in-vivo open flow microperfusion methods for direct and absolute quantification of albumin in interstitial fluid

Authors Hummer, Joanna; Schwingenschuh, Simon; Raml, Reingard; Boulgaropoulos, Beate; Schwagerle, Gerd; Augustin, Thomas; Sinner, Frank; Birngruber, Thomas
OFM recirculation and OFM suction: Advanced in-vivo open flow microperfusion methods for direct and absolute quantification of albumin in interstitial fluid
Health
2020

Evaluating Dermal Pharmacokinetics and Pharmacodymanic Effect of Soft Topical PDE4 Inhibitors: Open Flow Microperfusion and Skin Biopsies

Authors Eirefelt, Stefan; Hummer, Joanna; Basse, Line Hollesen; Bertelsen, Malene; Johansson, Fredrik; Birngruber, Thomas; Sinner, Frank; Larsen, Jens; Nielsen, Simon Feldbæk; Lambert, Maja
Evaluating Dermal Pharmacokinetics and Pharmacodymanic Effect of Soft Topical PDE4 Inhibitors: Open Flow Microperfusion and Skin Biopsies
Health
2019

Comparison of cerebral Open Flow Microperfusion and Microdialysis when sampling small lipophilic and small hydrophilic substances

Authors Altendorfer-Kroath, Thomas; Schimek, Denise; Eberl, Anita; Rauter, Günther; Ratzer, Maria; Raml, Reingard; Sinner, Frank; Birngruber, Thomas
Comparison of cerebral Open Flow Microperfusion and Microdialysis when sampling small lipophilic and small hydrophilic substances
Health
2019

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Authors Carmona-Gutierrez, Didac; Zimmermann, Andreas; Kainz, Katharina; Pietrocola, Federico; Chen, Guo; Maglioni, Silvia; Schiavi, Alfonso; Nah, Jihoon; Mertel, Sara; Beuschel, Christine B.; Castoldi, Francesca; Sica, Valentina; Trausinger, Gert; Raml, Reingard; Sommer, Cornelia; Schroeder, Sabrina; Hofer, Sebastian J.; Bauer, Maria A.; Pendl, Tobias; Tadic, Jelena; Dammbrueck, Christopher; Hu, Zehan; Ruckenstuhl, Christoph; Eisenberg, Tobias; Durand, Sylvere; Bossut, Noélie; Aprahamian, Fanny; Abdellatif, Mahmoud; Sedej, Simon; Enot, David P.; Wolinski, Heimo; Dengjel, Jörn; Kepp, Oliver; Magnes, Christoph; Sinner, Frank M.; Pieber, Thomas R.; Sadoshima, Junichi; Ventura, Natascia; Sigrist, Stephan J.; Kroemer, Guido; Madeo, Frank
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
Health
2019

LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation

Authors Pipper, Cornelia; Bordag, Natalie; Reiter, Bernadette; Economides, Kyriakos; Florian, Peter; Birngruber, Thomas; Sinner, Frank; Bodenlenz, Manfred; Eberl, Anita
LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation
Health
2019

Insulin distribution in human adipose tissue via a novel insulin infusion catheter

Authors Altendorfer‐Kroath, Thomas; Schwingenschuh, Simon; Schondorff-Kruse, Pernelle; Heschel, Matthias; Sinner, Frank; Birngruber, Thomas
Insulin distribution in human adipose tissue via a novel insulin infusion catheter
Health
2019

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

Authors Stekovic, Slaven; Hofer, Sebastian J.; Tripolt, Norbert; Aon, Miguel A.; Royer, Philipp; Pein, Lukas; Stadler, Julia T.; Pendl, Tobias; Prietl, Barbara; Url, Jasmin; Schroeder, Sabrina; Tadic, Jelena; Eisenberg, Tobias; Magnes, Christoph; Stumpe, Michael; Zuegner, Elmar; Bordag, Natalie; Riedl, Regina; Schmidt, Albrecht; Kolesnik, Ewald; Verheyen, Nicolas; Springer, Anna; Madl, Tobias; Sinner, Frank; de Cabo, Rafael; Kroemer, Guido; Obermayer-Pietsch, Barbara; Dengjel, Jöm; Sourij, Harald; Pieber, Thomas R.; Madeo, Frank
Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans
Health
2018

A comprehensive approach to qualify and validate the essential parameters of an in vitro release test (IVRT) method for acyclovir cream, 5%

Authors Tiffner, Katrin Irene; Kanfer, Isadore; Augustin, Thomas; Raml, Reingard; Raney, Sam G.; Sinner, Frank M.
A comprehensive approach to qualify and validate the essential parameters of an in vitro release test (IVRT) method for acyclovir cream, 5%
Health
2018

Quantification of acyclovir in dermal interstitial fluid and human serum by ultra-high-performance liquid-high-resolution tandem mass spectrometry for topical bioequivalence evaluation

Authors Schimek, Denise; Raml, Reingard; Francesconi, Kevin A.; Bodenlenz, Manfred; Sinner, Frank
Quantification of acyclovir in dermal interstitial fluid and human serum by ultra-high-performance liquid-high-resolution tandem mass spectrometry for topical bioequivalence evaluation
Health
2018

Development of a Protocol for Automated Glucose Measurement Transmission Used in Clinical Decision Support Systems Based on the Continua Design Guidelines

Authors Meyer, Markus; Donsa, Klaus; Truskaller, Thomas; Frohner, Matthias; Pohn, B; Felfernig, A; Sinner, F; Pieber, Thomas R
Development of a Protocol for Automated Glucose Measurement Transmission Used in Clinical Decision Support Systems Based on the Continua Design Guidelines
Health
2018

Intelligent NFC potassium measurement strip with hemolysis check in capillary blood

Authors Kollegger, Carolin; Greiner, Philipp; Siegl, Inge; Steffan, Christoph; Wiessflecker, Martin; Pekec, Bruna; Hajnsek, Martin; Sinner, Frank; Holweg, Gerald; Deutschmann, Bernd
Intelligent NFC potassium measurement strip with hemolysis check in capillary blood
Health
2017

Assessment of skin permeability to topically applied drugs by skin impedance and admittance.

Authors Schwingenschuh, Simon; Scharfetter, Hermann; Martinsen, Orjan Grottem; Boulgaropoulos, Beate; Augustin, Thomas; Tiffner, Katrin Irene; Dragatin, Christian; Raml, Reingard; Hoefferer, Christian; Prandl, Eva-Christina; Sinner, Frank M.; Hajnsek, Martin
Assessment of skin permeability to topically applied drugs by skin impedance and admittance.
Health
2017

Quantification of Basal Insulin Peglispro and Human Insulin in Adipose Tissue Interstitial Fluid by Open-Flow Microperfusion

Authors Tiffner, Katrin Irene; Boulgaropoulos, Beate; Höfferer, Christian; Birngruber, Thomas; Porksen, Niels; Linnebjerg, Helle; Garhyan, Parag; Lam, Eric Chen Quin; Knadler, Mary Pat; Pieber, Thomas R; Sinner, Frank M.
Quantification of Basal Insulin Peglispro and Human Insulin in Adipose Tissue Interstitial Fluid by Open-Flow Microperfusion
Health
2017

Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence

Authors Bodenlenz, Manfred; Tiffner, Katrin Irene; Raml, Reingard; Augustin, Thomas; Dragatin, Christian; Birngruber, Thomas; Schimek, Denise; Schwagerle, Gerd; Pieber, Thomas R.; Raney, Sam G.; Kanfer, Isadore; Sinner, Frank
Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence
Health
2017

β-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis

Authors Kolbinger, Frank; Loesche, Christian; Valentin, Marie-Anne; Jiang, Xiaoyu; Cheng, Yi; Jarvis, Philip; Peters, Thomas; Calonder, Claudio; Bruin, Gerard; Polus, Florine; Aigner, B; Lee, David M.; Bodenlenz, Manfred; Sinner, Frank; Pieber, Thomas R; Patel, Dhavalkumar D.
β-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis
Health
2017

First application of a transcutaneous optical single-port glucose monitoring device in patients with type 1 diabetes mellitus.

Authors Rumpler, M; Mader, J K; Fischer, J P; Thar, R; Granger, J M; Deliane, F; Klimant, I; Aberer, F; Sinner, Frank M.; Pieber, Thomas R; Hajnsek, M
First application of a transcutaneous optical single-port glucose monitoring device in patients with type 1 diabetes mellitus.
Health
2017

An in vitro and in vivo study of peptide-functionalized nanoparticles for brain targeting: The importance of selective blood-brain barrier uptake

Authors Bode, Gerard H; Coué, Grégory; Freese, Christian; Pickl, Karin E; Sanchez-Purrà, Maria; Albaiges, Berta; Borrós, Salvador; van Winden, Ewoud C; Tziveleka, Leto-Aikaterini; Sideratou, Zili; Engbersen, Johan F; Singh, Smriti; Albrecht, Krystyna; Groll, Jürgen; Möller, Martin; Pötgens, Andy J G; Schmitz, Christoph; Fröhlich, Eleonore Esther E.; Grandfils, Christian; Sinner, Frank M; Kirkpatrick, C James; Steinbusch, Harry W M; Frank, Hans-Georg; Unger, Ronald E; Martinez-Martinez, Pilar
An in vitro and in vivo study of peptide-functionalized nanoparticles for brain targeting: The importance of selective blood-brain barrier uptake
Health
2016

An Untargeted Metabolomics Approach to Characterize Short-Term and Long-Term Metabolic Changes after Bariatric Surgery

Authors Narath, Sophie H.; Mautner, Selma I.; Svehlikova, Eva; Schultes, Bernd; Pieber, Thomas R.; Sinner, Frank M.; Gander, Edgar; Libiseller, Gunnar; Schimek, Michael G.; Sourij, Harald; Magnes, Christoph
An Untargeted Metabolomics Approach to Characterize Short-Term and Long-Term Metabolic Changes after Bariatric Surgery
Health
2016

Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion.

Authors Dragatin, Christian; Polus, Florine; Bodenlenz, Manfred; Calonder, Claudio; Aigner, Birgit; Tiffner, Katrin Irene; Mader, Julia Katharina; Ratzer, Maria; Woessner, Ralph; Pieber, Thomas R; Cheng, Yi; Loesche, Christian; Sinner, Frank M.; Bruin, Gerard
Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion.
Health
2016

Kinetics of Clobetasol-17-Propionate in Psoriatic Lesional and Non-Lesional Skin Assessed by Dermal Open Flow Microperfusion with Time and Space Resolution

Authors Bodenlenz, Manfred; Dragatin, Christian; Liebenberger, Lisa; Tschapeller, Bernd; Boulgaropoulos, Beate; Augustin, Thomas; Raml, Reingard; Gatschelhofer, Christina; Wagner, Nathalie; Benkali, Khaled; Rony, Francois; Pieber, Thomas; Sinner, Frank
Kinetics of Clobetasol-17-Propionate in Psoriatic Lesional and Non-Lesional Skin Assessed by Dermal Open Flow Microperfusion with Time and Space Resolution
Health
2016

Determination of (2)H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography - quadrupole-mass-spectrometry

Authors Eberl, A; Altendorfer‐Kroath, Thomas; Kollmann, D; Birngruber, Thomas; Sinner, F; Raml, R; Magnes, Christoph
Determination of (2)H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography - quadrupole-mass-spectrometry
Health
2016

Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue

Authors Birngruber, Thomas; Sinner, Frank
Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue
Health
2016

Interleukin-17A blockade with secukinumab results in decreased neutrophil infiltration in psoriasis: minimally-invasive measurement by tape stripping

Authors Loesche, Christian; Kolbinger, Frank; Valentin, Marie-anne; Jarvis, Philip; Ceci, Melanie; Wieczorek, Grazyna; Khokhlovich, Edward; Koroleva, Irina; Bruin, Gerard; Sinner, Frank M.; Aigner, B; Patel, Dhavalkumar D
Interleukin-17A blockade with secukinumab results in decreased neutrophil infiltration in psoriasis: minimally-invasive measurement by tape stripping
Health
2015

IPO: a tool for automated optimization of XCMS parameters

Authors Libiseller, Gunnar; Dvorzak, Michaela; Kleb, Ulrike; Gander, Edgar; Eisenberg, Tobias; Madeo, Frank; Neumann, Steffen; Trausinger, Gert; Sinner, Frank; Pieber, Thomas; Magnes, Christoph
IPO: a tool for automated optimization of XCMS parameters
Health
2015

Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin

Authors Braun, Ralf J.; Sommer, Cornelia; Leibiger, Christine; Gentier, Romina J.G.; Dumit, Verónica I.; Paduch, Katrin; Eisenberg, Tobias; Habernig, Lukas; Trausinger, Gert; Magnes, Christoph; Pieber, Thomas; Sinner, Frank; Dengjel, Jörn; van Leeuwen, Fred W.; Kroemer, Guido; Madeo, Frank
Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin
Health
2015

Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast

Authors Braun, Ralf J.; Sommer, Cornelia; Leibiger, Christine; Gentier, Romina; Dumit, Veronica; Paduch, Katrin; Eisenberg, Tobias; Habernig, Lukas; Trausinger, Gert; Magnes, Christoph; Pieber, Thomas R; Sinner, Frank M; Dengjel, Jörn; van Leeuwen, Fred; Kroemer, Guido; Madeo, Frank
Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast
Health
2015

Open flow microperfusion: pharmacokinetics of human insulin and insulin detemir in the interstitial fluid of subcutaneous adipose tissue.

Authors Höfferer, C; Tutkur, D; Fledelius, C; Brand, C L; Alsted, T J; Damgaard, J; Nishimura, E; Jeppesen, C B; Mautner, S. I.; Pieber, Thomas R; Sinner, Frank M.
Open flow microperfusion: pharmacokinetics of human insulin and insulin detemir in the interstitial fluid of subcutaneous adipose tissue.
Health
2015

An electrochemical sensor for fast detection of wound infection based on myeloperoxidase activity

Authors Hajnsek, Martin; Schiffer, Doris; Harrich, Daniel; Koller, Daniel; Verient, Vanessa; Palen, Job V.D. D; Heinzle, Andrea; Binder, Barbara; Sigl, Eva; Sinner, Frank M.; Guebitz, Georg M.
An electrochemical sensor for fast detection of wound infection based on myeloperoxidase activity
Health
2014

Enhanced Doxorubicin Delivery to the Brain Administered Through Glutathione PEGylated Liposomal Doxorubicin (2B3-101) as Compared with Generic Caelyx,®/Doxil®—A Cerebral Open Flow Microperfusion Pilot Study

Authors Birngruber, Thomas; Raml, Reingard; Gladdines, Werner; Gatschelhofer, Christina; Gander, Edgar; Ghosh, Arijit; Kroath, Thomas; Gaillard, Pieter J; Pieber, Thomas R; Sinner, Frank
Enhanced Doxorubicin Delivery to the Brain Administered Through Glutathione PEGylated Liposomal Doxorubicin (2B3-101) as Compared with Generic Caelyx,®/Doxil®—A Cerebral Open Flow Microperfusion Pilot Study
Health
2014

Assessment of blood-brain barrier function and the neuroinflammatory response in the rat brain by using cerebral open flow microperfusion (cOFM).

Authors Ghosh, Arijit; Birngruber, Thomas; Sattler, Wolfgang; Kroath, Thomas; Ratzer, Maria; Sinner, Frank M.; Pieber, Thomas R
Assessment of blood-brain barrier function and the neuroinflammatory response in the rat brain by using cerebral open flow microperfusion (cOFM).
Health
2014

Long-Term Implanted cOFM Probe Causes Minimal Tissue Reaction in the Brain

Authors Birngruber, Thomas; Ghosh, Arijit; Hochmeister, Sonja; Asslaber, Martin; Kroath, Thomas; Pieber, Thomas R.; Sinner, Frank
Long-Term Implanted cOFM Probe Causes Minimal Tissue Reaction in the Brain
Health
2013

Clinical applicability of dOFM devices for dermal sampling.

Authors Bodenlenz, Manfred; Aigner, B; Dragatin, C; Liebenberger, L; Zahiragic, S; Höfferer, C; Birngruber, Thomas; Priedl, J; Feichtner, F; Schaupp, L; Korsatko, S; Ratzer, M; Magnes, Christoph; Pieber, Thomas R; Sinner, F
Clinical applicability of dOFM devices for dermal sampling.
Health
2013

Spermidine promotes mating and fertilization efficiency in model organisms

Authors Bauer, Maria Anna; Carmona-Gutiérrez, Didac; Ruckenstuhl, Christoph; Reisenbichler, Angela; Megalou, Evgenia V.; Eisenberg, Tobias; Magnes, Christoph; Jungwirth, Helmut; Sinner, Frank M; Pieber, Thomas R; Fröhlich, Kai Uwe; Kroemer, Guido; Tavernarakis, Nektarios; Madeo, Frank
Spermidine promotes mating and fertilization efficiency in model organisms
Health
2013

Design and physicochemical characterization of poly(amidoamine) nanoparticles and the toxicological evaluation in human endothelial cells: applications to peptide delivery to the brain

Authors Coué, Grégory; Freese, Christian; Unger, Ronald E; Kirkpatrick, C James; Pickl, Karin E; Sinner, Frank M; Engbersen, Johan F J
Design and physicochemical characterization of poly(amidoamine) nanoparticles and the toxicological evaluation in human endothelial cells: applications to peptide delivery to the brain
Health
2013

Enhanced absorption of insulin aspart as the result of a dispersed injection strategy tested in a randomized trial in type 1 diabetic patients

Authors Mader, Julia K; Birngruber, Thomas; Korsatko, Stefan; Deller, Sigrid; Köhler, Gerd; Boysen, Susanne; Augustin, Thomas; Mautner, Selma; Sinner, Frank; Pieber, Thomas R; AP@home Consortium
Enhanced absorption of insulin aspart as the result of a dispersed injection strategy tested in a randomized trial in type 1 diabetic patients
Health
2013

Cerebral open flow microperfusion: a new in vivo technique for continuous measurement of substance transport across the intact blood-brain barrier.

Authors Birngruber, Thomas; Ghosh, Arijit; Perez-Yarza, Veronica; Kroath, Thomas; Ratzer, Maria; Pieber, Thomas R; Sinner, Frank M.
Cerebral open flow microperfusion: a new in vivo technique for continuous measurement of substance transport across the intact blood-brain barrier.
Health, Materials
2013

Design and evaluation of a microfluidic-based whole blood pre-treatment module to detect folic acid.

Authors Rumpler, M.; Suppan, M.; Hajnsek, M.; Satzinger, V.; Köstler, St; Sinner, F.
Design and evaluation of a microfluidic-based whole blood pre-treatment module to detect folic acid.
Health
2012

Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling

Authors Bodenlenz, Manfred; Höfferer, Christian; Magnes, Christoph; Schaller-Ammann, Roland; Schaupp, Lukas; Feichtner, Franz; Ratzer, Maria; Pickl, Karin; Sinner, Frank; Wutte, Andrea; Korsatko, Stefan; Köhler, Gerd; Legat, Franz J.; Benfeldt, Eva M.; Wright, Andrew M.; Neddermann, Daniel; Jung, Thomas; Pieber, Thomas R
Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling
Health
2012

Remodeling of lipid droplets during lipolysis and growth in adipocytes

Authors Paar, Margret; Jüngst, Christian; Steiner, Noemi A.; Magnes, Christoph; Sinner, Frank; Kolb, Dagmar; Lass, Achim; Zimmermann, Robert; Zumbusch, Andreas; Kohlwein, Sepp D.; Wolinski, Heimo
Remodeling of lipid droplets during lipolysis and growth in adipocytes
Health
2012

Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury

Authors Moustafa, Tarek; Fickert, Peter; Magnes, Christoph; Guelly, Christian; Thueringer, Andrea; Frank, Sasa; Kratky, Dagmar; Sattler, Wolfgang; Reicher, Helga; Sinner, Frank; Gumhold, Judith; Silbert, Dagmar; Fauler, Günter; Höfler, Gerald; Lass, Achim; Zechner, Rudolf; Trauner, Michael
Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury
Health
2012

Monolithic precolumns as efficient tools for guiding the design of nanoparticulate drug-delivery formulations

Authors Gatschelhofer, Christina; Prasch, Agnes; Buchmeiser, Michael R; Zimmer, Andreas; Wernig, Karin; Griesbacher, Martin; Pieber, Thomas R; Sinner, Frank M
Monolithic precolumns as efficient tools for guiding the design of nanoparticulate drug-delivery formulations
Health
2012

Open Flow Microperfusion: An Alternative Method to Microdialysis?

Authors Pieber, Thomas R; Birngruber, Thomas; Bodenlenz, Manfred; Höfferer, Christian; Mautner, S. I.; Tiffner, Katrin Irene; Sinner, Frank M.
Open Flow Microperfusion: An Alternative Method to Microdialysis?
Health
2012

Comparison of Open-Flow Microperfusion and Microdialysis Methodologies When Sampling Topically Applied Fentanyl and Benzoic Acid in Human Dermis Ex Vivo

Authors Holmgaard, Rikke; Benfeldt, E; Nielsen, J B; Gatschelhofer, C; Sorensen, J a; Höfferer, C; Bodenlenz, Manfred; Pieber, Thomas R; Sinner, F.
Comparison of Open-Flow Microperfusion and Microdialysis Methodologies When Sampling Topically Applied Fentanyl and Benzoic Acid in Human Dermis Ex Vivo
Health
2011

Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats

Authors Ardjomand-Woelkart, Karin; Kollroser, Manfred; Magnes, Christoph; Sinner, Frank; Frye, Reginald F; Derendorf, Hartmut; Bauer, Rudolf; Butterweck, Veronika
Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats
Health
2011

The propeptide of yeast cathepsin D inhibits programmed necrosis

Authors Carmona-Gutiérrez, D; Bauer, M A; Ring, J; Knauer, H; Eisenberg, T; Büttner, S; Ruckenstuhl, C; Reisenbichler, A; Magnes, C; Rechberger, G N; Birner-Gruenberger, R; Jungwirth, H; Fröhlich, K-U; Sinner, F; Kroemer, G; Madeo, F
The propeptide of yeast cathepsin D inhibits programmed necrosis
Health
2011

Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment

Authors Painsipp, Evelin; Köfer, Martin J.; Sinner, Frank; Holzer, Peter
Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment
Health
2011

Headspace-SPME-GC/MS as a simple cleanup tool for sensitive 2,6-diisopropylphenol analysis from lipid emulsions and adaptable to other matrices

Authors Pickl, Karin E; Adamek, Viktor; Gorges, Roland; Sinner, Frank M
Headspace-SPME-GC/MS as a simple cleanup tool for sensitive 2,6-diisopropylphenol analysis from lipid emulsions and adaptable to other matrices
Health
2011

The use of chitosan-6-mercaptonicotinic acid nanoparticles for oral peptide drug delivery

Authors Millotti, Gioconda; Perera, Glen; Vigl, Claudia; Pickl, Karin; Sinner, Frank Michael; Bernkop-Schnürch, Andreas
The use of chitosan-6-mercaptonicotinic acid nanoparticles for oral peptide drug delivery
Health
2010

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase

Authors Chandak, Prakash G.; Radović, Branislav; Aflaki, Elma; Kolb, Dagmar; Buchebner, Marlene; Fröhlich, Eleonore; Magnes, Christoph; Sinner, Frank; Haemmerle, Guenter; Zechner, Rudolf; Tabas, Ira; Levak-Frank, Sanja; Kratky, Dagmar
Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase
Health
2009

Induction of autophagy by spermidine promotes longevity

Authors Eisenberg, Tobias; Knauer, Heide; Schauer, Alexandra; Büttner, Sabrina; Ruckenstuhl, Christoph; Carmona-Gutierrez, Didac; Ring, Julia; Schroeder, Sabrina; Magnes, Christoph; Antonacci, Lucia; Fussi, Heike; Deszcz, Luiza; Hartl, Regina; Schraml, Elisabeth; Criollo, Alfredo; Megalou, Evgenia; Weiskopf, Daniela; Laun, Peter; Heeren, Gino; Breitenbach, Michael; Grubeck-Loebenstein, Beatrix; Herker, Eva; Fahrenkrog, Birthe; Fröhlich, Kai-Uwe; Sinner, Frank; Tavernarakis, Nektarios; Minois, Nadege; Kroemer, Guido; Madeo, Frank
Induction of autophagy by spermidine promotes longevity
Health
2009

Ring-opening metathesis polymerization for the preparation of norbornene-based weak cation-exchange monolithic capillary columns

Authors Gatschelhofer, Christina; Mautner, Agnes; Reiter, Franz; Pieber, Thomas R; Buchmeiser, Michael R; Sinner, Frank M
Ring-opening metathesis polymerization for the preparation of norbornene-based weak cation-exchange monolithic capillary columns
Health
2008

Insulin glulisine, insulin lispro and regular human insulin show comparable end-organ metabolic effects: an exploratory study

Authors Horvath, K; Bock, G; Regittnig, W; Bodenlenz, Manfred; Wutte, A; Plank, J; Magnes, Christoph; Sinner, F.; Fürst-Recktenwald, S.; Theobald, K; Pieber, Thomas R
Insulin glulisine, insulin lispro and regular human insulin show comparable end-organ metabolic effects: an exploratory study
Health
2008

Ring-opening metathesis polymerization-derived monolithic capillary columns for high-performance liquid chromatography. Downscaling and application in medical research

Authors Sinner, Frank M; Gatschelhofer, Christina; Mautner, Agnes; Magnes, Christoph; Buchmeiser, Michael R; Pieber, Thomas R
Ring-opening metathesis polymerization-derived monolithic capillary columns for high-performance liquid chromatography. Downscaling and application in medical research
Health
2008

Validated comprehensive analytical method for quantification of coenzyme A activated compounds in biological tissues by online solid-phase extraction LC/MS/MS.

Authors Magnes, Christoph; Suppan, Maria; Pieber, Thomas R; Moustafa, Tarek; Trauner, Michael; Haemmerle, Guenter; Sinner, Frank M
Validated comprehensive analytical method for quantification of coenzyme A activated compounds in biological tissues by online solid-phase extraction LC/MS/MS.
Health
2007

Proportional Dose-Response Relationship and Lower Within-Patient Variability of Insulin Detemir and NPH Insulin in Subjects With Type 1 Diabetes Mellitus

Authors Wutte, A; Plank, J; Bodenlenz, Manfred; Magnes, Christoph; Regittnig, W; Sinner, F.; Rønn, B.; Zdravkovic, M; Pieber, T.
Proportional Dose-Response Relationship and Lower Within-Patient Variability of Insulin Detemir and NPH Insulin in Subjects With Type 1 Diabetes Mellitus
Health
2007

Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion

Authors Pickl, Karin E.; Magnes, Christoph; Bodenlenz, Manfred; Pieber, Thomas R.; Sinner, Frank M.
Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion
Health
2007

Voltage-assisted capillary LC of peptides using monolithic capillary columns prepared by ring-opening metathesis polymerization

Authors Sedláková, Pavla; Miksik, Ivan; Gatschelhofer, Christina; Sinner, Frank M; Buchmeiser, Michael R
Voltage-assisted capillary LC of peptides using monolithic capillary columns prepared by ring-opening metathesis polymerization
Health
2006

Enantioseparation of glycyl-dipeptides by CEC using particle-loaded monoliths prepared by ring-opening metathesis polymerization (ROMP)

Authors Gatschelhofer, Christina; Schmid, Martin G; Schreiner, Karin; Pieber, Thomas R; Sinner, Frank M; Gübitz, Gerald
Enantioseparation of glycyl-dipeptides by CEC using particle-loaded monoliths prepared by ring-opening metathesis polymerization (ROMP)
Health
2006

Poly(cyclooctene)-based monolithic columns for capillary high performance liquid chromatography prepared via ring-opening metathesis polymerization

Authors Schlemmer, Bettina; Gatschelhofer, Christina; Pieber, Thomas R; Sinner, Frank M; Buchmeiser, Michael R
Poly(cyclooctene)-based monolithic columns for capillary high performance liquid chromatography prepared via ring-opening metathesis polymerization
Health
2005

A Double-Blind, Randomized, Dose-Response Study Investigating the Pharmacodynamic and Pharmacokinetic Properties of the Long-Acting Insulin Analog Detemir

Authors Plank, Johannes; Bodenlenz, Manfred; Sinner, Frank; Magnes, Christoph; Görzer, Evelyn; Regittnig, Werner; Endahl, Lars A.; Draeger, Eberhard; Zdravkovic, Milan; Pieber, Thomas R
A Double-Blind, Randomized, Dose-Response Study Investigating the Pharmacodynamic and Pharmacokinetic Properties of the Long-Acting Insulin Analog Detemir
Health
2005

LC/MS/MS Method for Quantitative Determination of Long-Chain Fatty Acyl-CoAs

Authors Magnes, Christoph; Sinner, Frank M; Regittnig, Werner; Pieber, Thomas R
LC/MS/MS Method for Quantitative Determination of Long-Chain Fatty Acyl-CoAs
Health
2005

Evaluation of ring-opening metathesis polymerization (ROMP)-derived monolithic capillary high performance liquid chromatography columns

Authors Gatschelhofer, Christina; Magnes, Christoph; Pieber, Thomas R; Buchmeiser, Michael R; Sinner, Frank M
Evaluation of ring-opening metathesis polymerization (ROMP)-derived monolithic capillary high performance liquid chromatography columns
Health
2005

Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access

Authors Bodenlenz, Manfred; Schaupp, Lukas A; Druml, Tatjana; Sommer, Romana; Wutte, Andrea; Schaller, Helga C; Sinner, Frank; Wach, Paul; Pieber, Thomas R
Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access
Health
2000

Ring-Opening Metathesis Polymerization: Access to a New Class of Functionalized, Monolithic Stationary Phases for Liquid Chromatography

Authors Sinner, Frank Michael; Buchmeiser, Michael Rudolf
Ring-Opening Metathesis Polymerization: Access to a New Class of Functionalized, Monolithic Stationary Phases for Liquid Chromatography
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