With cOFM, local drug distribution and biomarkers in the brain can be monitored - with the blood-brain barrier intact.
The blood-brain barrier (BBB) protects the brain from harmful substances, toxins, etc., but also hinders the transport of neuropharmaceuticals into the brain. The cOFM (cerebral Open Microperfusion) allows sampling in numerous brain regions with an intact BBB. cOFM studies provide data for drug development as well as unique insights into metabolism and signaling in the brain.
About cOFM
cOFM is a unique instrument for investigating the pharmacokinetics (PK) and pharmacodynamics (PD) of the brain with an intact BBB. Implantation of a sample into the brain region under investigation leads to rupture of the blood vessels and local destruction of the BBB. When performing cOFM experiments, the BBB is healed and restored for 2 weeks after implantation of the cOFM probe so that cOFM sampling can then be performed with the BBB intact. During sampling, the cOFM sample is continuously perfused with a physiological fluid (perfusate). The perfusate exchanges molecules with the cerebral interstitial fluid (ISF), resulting in diluted and also unfiltered cerebral ISF samples. The collected cerebral ISF samples contain all molecules present in the brain tissue without restriction due to size or inherent chemical properties, including drugs, proteins and antibodies.
cOFM features
Fast and efficient PK-based bioequivalence studies for topical generics
Unique de-risking and proof-of-mechanism studies for dermal active ingredients
Specialized methods for analyses and testing for preclincial and clinical studies (GLP and non-GLP).
Instruments and methods for the measurement of pharmacokinetics and pharmacodynamics in different tissues.
Comprehensive and compliant data management and biostatistics for clinical trials
We test drug release in a fast and reliable way using IVRT based on vertical diffusion cells and synthetic membranes.
We perform untargeted and targeted metabolomics studies to quantify metabolites to investigate metabolic processes and identify biomarkers.
The digital checklist and cross-professional process documentation for surgical procedures.
We offer extensive, professional support in reporting and publishing the results of your preclinical and clinical studies.
aOFM can be used to monitor local drug distribution and biomarkers in subcutaneous adipose tissue.
Unlock success in regulatory compliance for medical devices with tailored, hands-on guidance
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