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Open Flow Microperfusion

Instruments and methods for the measurement of pharmacokinetics and pharmacodynamics in different tissues.

Open Flow Microperfusion (OFM) - Technology

OFM enables the continuous collection of interstitial fluid in (pre)clinical studies for drug development and biomarker research.

OFM is a patented, catheter-based and membrane-free method for the continuous collection of minute amounts of interstitial fluid from various tissues. It enables access to the entire biochemical information of the interstitium and thus opens up completely new perspectives in preclinical and clinical (pharmacological) research and drug testing. The membrane-free OFM catheters have an exchange surface without a diffusion barrier, so that sampling is not restricted by the size, lipophilicity of substances or protein binding effects.

  • Applications: pharmacokinetics, pharmacodynamics, bioequivalence, bioavailability, dose finding, drug metabolism
  • Substances: active ingredients (low molecular weight to antibody-based; fat and water-soluble), endogenous substances (substances ranging from small molecules to cells)
  • Preclinical models: pig, rat, mouse
  • Tissue: skin, mucous membrane, brain, muscle, fatty tissue, lymph, cancer


Preclinical Research

We manufacture OFM materials for preclinical studies and distribute them worldwide. 

  • Products: information on the various OFM products, our product catalog, application videos, FAQs or the instructions for use can be found here
  • Sales regions and countries: Europe, North, Central and South America, Japan, China, South Korea, Hong Kong, Singapore, Australia, Russia, Israel, India. Write us and we will put you in touch with your local sales partner.


Clinical Research

  • OFM-Materialien für klinische Studien sind als Medizinprodukte zugelassen und CE zertifiziert
  • Applications: skin, muscle, fatty tissue
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