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Mag. Dr. Christoph Magnes

Funktion

Forschungsgruppenleitung

Forschungsgruppe

HEALTH:

Bioanalytik und Metabolomics

Telefon

+43 316 876-4201

E-Mail

Christoph.Magnes@joanneum.at

Adresse

Neue Stiftingtalstraße 2, 8010, Graz
+43 316 876-4000
health@joanneum.at

Publikationen

Health
2025

Lipid Ratios for Diagnosis and Prognosis of Pulmonary Hypertension

Autor*innen: Natalie Bordag, Bence Miklos Nagy, Elmar Zügner, Helga Ludwig, Vasile Foris, Chandran Nagaraj, Valentina Biasin, Gabor Kovacs, Nikolaus Kneidinger, Ulrich Bodenhofer, Christoph Magnes, Bradley A Maron, Silvia Ulrich, Tobias J Lange, Thomas O Eichmann, Konrad Hoetzenecker, Thomas Pieber, Horst Olschewski, Andrea Olschewski
Lipid Ratios for Diagnosis and Prognosis of Pulmonary Hypertension
Health
2025

Cerebral open flow microperfusion (cOFM)-HILIC-HRMS platform for in vivo and in situ monitoring of tumor microenvironment in glioblastoma

Autor*innen: Fernanda Monedeiro, Denise Schimek, Eva-Maria Prugger, Thomas Altendorfer-Kroath, Elmar Zügner, Christoph Magnes
Cerebral open flow microperfusion (cOFM)-HILIC-HRMS platform for in vivo and in situ monitoring of tumor microenvironment in glioblastoma
Health
2024

Implementation and validation of a UHPLC-MS/MS method for quantification of the endocannabinoids AEA and 2-AG in cerebral interstitial fluid and plasma

Autor*innen: Weiermeier T, Svehlikova E, Magnes C, Boulgaropoulos B, Altendorfer-Kroath T, Hummer J, Eberl A
Implementation and validation of a UHPLC-MS/MS method for quantification of the endocannabinoids AEA and 2-AG in cerebral interstitial fluid and plasma
Health
2024

Enzymatic detection of α-hydroxybutyrate, an important marker of insulin resistance, and comparison with LC-MS/MS detection

Autor*innen: Steiner B, Leitner C, Stadler D, Prugger E, Magnes C, Herzog P
Enzymatic detection of α-hydroxybutyrate, an important marker of insulin resistance, and comparison with LC-MS/MS detection
Health
2024

Investigating Runner’s High: Changes in Mood and Endocannabinoid Concentrations after a 60 min Outdoor Run Considering Sex, Running Frequency, and Age

Autor*innen: Weiermair, T., Svehlikova, E., Boulgaropoulos, B., Magnes, C.; Eberl, A.
Investigating Runner’s High: Changes in Mood and Endocannabinoid Concentrations after a 60 min Outdoor Run Considering Sex, Running Frequency, and Age
Health
2024

Spermidine is essential for fasting-mediated autophagy and longevity

Autor*innen: Hofer, S. J., Daskalaki, I., Bergmann, M., Friščić, J., Zimmermann, A., Mueller, M. I., Abdellatif, M., Nicastro, R., Masser, S., Durand, S., Nartey, A., Waltenstorfer, M., Enzenhofer, S., Faimann, I., Gschiel, V., Bajaj, T., Niemeyer, C., Gkikas, I., Pein, L., Cerrato, G., Pan, H., Lian, Y., Tadic, J., Jerkovic, A., Aprahamian, F., Robbins, C., Nirmalathasan, N., Habisch, H., Annerer, E., Dethloff, F., Stumpe, M., Grundler, F., Wilhelmi de Toledo, F., Heinz, D., Koppold, D., Rajput Khokhar, A., Michalsen, A., Tripolt, N., Sourij, H., Pieber, T., de Cabo, R., McCormick M., Magnes, C., Kepp, O., Dengjel, J., Sigrist, S., Gassen, N., Sedej, S., Madl, T., De Virgilio C, Stelzl, U., Hoffmann, M., Eisenberg, T., Tavernarakis, N., Kroemer, G., Madeo, F.
Spermidine is essential for fasting-mediated autophagy and longevity
Health
2024

Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopic Dermatitis

Autor*innen: Monedeiro, F., Ehall, B., Tiffner, K., Eberl, A., Svehlikova, E., Prietl, B., Pfeifer, V., Senekowitsch, J., Remm, A., Rebane, A., Magnes, C., Pieber, T., Sinner, F., & Birngruber, T.
Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopic Dermatitis
Health
2023

Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models

Autor*innen: Costa-Machado, Luis Filipe; Garcia-Dominguez, Esther; McIntyre, Rebecca L; Lopez-Aceituno, Jose Luis; Ballesteros-Gonzalez, Álvaro; Tapia-Gonzalez, Andrea; Fabregat-Safont, David; Eisenberg, Tobias; Gomez, Jesús; Plaza, Adrian; Sierra-Ramirez, Aranzazu; Perez, Manuel; Villanueva-Bermejo, David; Fornari, Tiziana; Loza, María Isabel; Herradon, Gonzalo; Hofer, Sebastian J; Magnes, Christoph; Madeo, Frank; Duerr, Janet S; Pozo, Oscar J; Galindo, Maximo-Ibo; del Pino, Isabel; Houtkooper, Riekelt H; Megias, Diego; Viña, Jose; Gomez-Cabrera, Mari Carmen; Fernandez-Marcos, Pablo J
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Health
2023

H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase

Autor*innen: Ravindran Menon, Dinoop; Hammerlindl, Heinz; Gimenez, Gregory; Hammerlindl, Sabrina; Zuegner, Elmar; Torrano, Joachim; Bordag, Natalie; Emran, Abdullah Al; Giam, Maybelline; Denil, Simon; Pavelka, Norman; Tan, Aik-Choon; Sturm, Richard A.; Haass, Nikolas K.; Rancati, Giulia; Herlyn, Meenhard; Magnes, Christoph; Eccles, Michael R.; Fujita, Mayumi; Schaider, Helmut
H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase
Health
2023

Metabolic support by macrophages sustains colonic epithelial homeostasis

Autor*innen: Fritsch S, Sukhbaatar N, Gonzales K, Sahu A, Tran L, Vogel A, Mazic M, Wilson J, Forisch S, Mayr H, Oberle R, Weiszmann J, Brenner M, Vanhoutte R, Hofmann M, Pirnes-Karhu S, Magnes C, Kühnast T, Weckwerth W, Bock C, Klavins K, Hengstschläger M, MOissl-Eichinger C, Schabbauer G, Egger G, Pirinen E, Verhelst S, Weichhart T
Metabolic support by macrophages sustains colonic epithelial homeostasis
Health
2022

Alterations in the Kynurenine–Tryptophan Pathway and Lipid Dysregulation Are Preserved Features of COVID-19 in Hemodialysis

Autor*innen: Schuller, Max; Oberhuber, Monika; Prietl, Barbara; Zügner, Elmar; Prugger, Eva-maria; Magnes, Christoph; Kirsch, Alexander H; Schmaldienst, Sabine; Pieber, Thomas; Brodmann, Marianne; Rosenkranz, Alexander R; Eller, Philipp; Eller, Kathrin
Alterations in the Kynurenine–Tryptophan Pathway and Lipid Dysregulation Are Preserved Features of COVID-19 in Hemodialysis
Health
2022

Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism

Autor*innen: Zügner, Elmar; Yang, Hsiu-Chiung; Kotzbeck, Petra; Boulgaropoulos, Beate; Sourij, Harald; Hagvall, Sepideh; Elmore, Charles S.; Esterline, Russell; Moosmang, Sven; Oscarsson, Jan; Pieber, Thomas R.; Peng, Xiao-Rong; Magnes, Christoph
Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism
Health
2022

Effect of Liraglutide Treatment on Whole-body Glucose Fluxes in C-peptide–Positive Type 1 Diabetes During Hypoglycemia

Autor*innen: Zenz, Sabine; Regittnig, Werner1; Boulgaropoulos, Beate; Augustin, Thomas; Brunner, Martina; Korsatko, Stefan; Münzker, Julia; Narath, Sophie H.; Raml, Reingard; Magnes, Christoph; Pieber, Thomas R
Effect of Liraglutide Treatment on Whole-body Glucose Fluxes in C-peptide–Positive Type 1 Diabetes During Hypoglycemia
Coremed, Health
2022

Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism

Autor*innen: Zügner E; Yang HC; Kotzbeck P ; Boulgaropoulos B; Sourij H; Hagvall S; Elmore CS; Esterline R; Moosmang S; Oscarsson J; Pieber TR; Peng XR; Magnes C
Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism
Coremed, Health
2022

The effect of spermidine on autoimmunity and beta cell function in NOD mice

Autor*innen: Karacay C; Prietl B; Harer C; Ehall B; Haudum CW; Bounab K; Franz J; Eisenberg T; Madeo F; Kolb D; Hingerl K; Hausl M; Magnes C; Mautner SI; Kotzbeck P ; Pieber TR
The effect of spermidine on autoimmunity and beta cell function in NOD mice
Health
2022

Insights into the Composition of a Co-Culture of 10 Probiotic Strains (OMNi BiOTiC® AAD10) and Effects of Its Postbiotic Culture Supernatant

Autor*innen: Kienesberger, Bernhard; Obermüller, Beate; Singer, Georg; Arneitz, Christoph; Gasparella, Paolo; Klymiuk, Ingeborg; Horvath, Angela; Stadlbauer, Vanessa; Magnes, Christoph; Zügner, Elmar; López-García, Pablo; Trajanoski, Slave; Miekisch, Wolfram; Fuchs, Patricia; Till, Holger; Castellani, Christoph
Insights into the Composition of a Co-Culture of 10 Probiotic Strains (OMNi BiOTiC® AAD10) and Effects of Its Postbiotic Culture Supernatant
Health
2022

Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline

Autor*innen: Schwarz, Claudia; Benson, Gloria S.; Horn, Nora; Wurdack, Katharina; Grittner, Ulrike; Schilling, Ralph; Märschenz, Stefanie; Köbe, Theresa; Hofer, Sebastian J.; Magnes, Christoph; Stekovic, Slaven; Eisenberg, Tobias; Sigrist, Stephan J.; Schmitz, Dietmar; Wirth, Miranka; Madeo, Frank; Flöel, Agnes
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline
Health
2022

Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions

Autor*innen: Paulus, Michael G.; Renner, Kathrin; Nickel, Alexander G.; Brochhausen, Christoph; Limm, Katharina; Zügner, Elmar; Baier, Maria J.; Pabel, Steffen; Wallner, Stefan; Birner, Christoph; Luchner, Andreas; Magnes, Christoph; Oefner, Peter J.; Stark, Klaus J.; Wagner, Stefan; Maack, Christoph; Maier, Lars S.; Streckfuss-Bömeke, Katrin; Sossalla, Samuel; Dietl, Alexander
Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions
Coremed +
2021

A novel human ex vivo skin model to study early local responses to burn injuries

Autor*innen: Hofmann, Elisabeth; Fink, Julia; Eberl, Anita; Prugger, Eva-Maria; Kolb, Dagmar; Luze, Hanna; Schwingenschuh, Simon; Birngruber, Thomas; Magnes, Christoph; Mautner, Selma I; Kamolz, Lars-Peter; Kotzbeck, Petra
A novel human ex vivo skin model to study early local responses to burn injuries
Health
2021

Dietary spermidine improves cognitive function

Autor*innen: Schroeder, Sabrina; Hofer, Sebastian J.; Zimmermann, Andreas; Pechlaner, Raimund; Dammbrueck, Christopher; Pendl, Tobias; Marcello, G. Mark; Pogatschnigg, Viktoria; Bergmann, Martina; Müller, Melanie; Gschiel, Verena; Ristic, Selena; Tadic, Jelena; Iwata, Keiko; Richter, Gesa; Farzi, Aitak; Üçal, Muammer; Schäfer, Ute; Poglitsch, Michael; Royer, Philipp; Mekis, Ronald; Agreiter, Marlene; Tölle, Regine C.; Sótonyi, Péter; Willeit, Johann; Mairhofer, Barbara; Niederkofler, Helga; Pallhuber, Irmgard; Rungger, Gregorio; Tilg, Herbert; Defrancesco, Michaela; Marksteiner, Josef; Sinner, Frank; Magnes, Christoph; Pieber, Thomas R.; Holzer, Peter; Kroemer, Guido; Carmona-Gutierrez, Didac; Scorrano, Luca; Dengjel, Jörn; Madl, Tobias; Sedej, Simon; Sigrist, Stephan J.; Rácz, Bence; Kiechl, Stefan; Eisenberg, Tobias; Madeo, Frank
Dietary spermidine improves cognitive function
Health
2021

Metabolic profiling of attached and detached metformin and 2-deoxy-D-glucose treated breast cancer cells

Autor*innen: Repas, Jernej; Zügner, Elmar; Gole, Boris; Bizjak, Marusa; Ptocnik, Uros; Magnes, Christoph; Pavlin, Mojca
Metabolic profiling of attached and detached metformin and 2-deoxy-D-glucose treated breast cancer cells
Health
2020

Pharmacokinetics and Pharmacodynamics of Three Different Formulations of Insulin Aspart: A Randomized, Double-blind, Crossover Study in Men With Type 1 Diabetes

Autor*innen: Svehlikova, Eva; Mursic, Ines; Augustin, Thomas; Magnes, Christoph; Gerring, David; Jezek, Jan; Schwarzenbacher, Daniela; Ratzer, Maria; Wolf, Michael; Howell, Sarah; Zakrzewski, Leon; Urschitz, Martina; Tschapeller, Bernd; Gatschelhofer, Christina; Feichtner, Franz; Lawrence, Fiona; Pieber, Thomas R.
Pharmacokinetics and Pharmacodynamics of Three Different Formulations of Insulin Aspart: A Randomized, Double-blind, Crossover Study in Men With Type 1 Diabetes
Health
2020

Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung

Autor*innen: Ahrendt, Nancy; Steingrüber, Tobias; Rajces, Alexandra; Lopez-Rodriguez, Elena; Eisenberg, Tobias; Magnes, Christoph; Madeo, Frank; Sedej, Simon; Schmiedl, Andreas; Ochs, Matthias; Mühlfeld, Christian; Schipke, Julia
Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung
Health
2020

Feasibility of rapidly assessing reactive impurities mediated excipient incompatibility using a new method: A case study of famotidine-PEG system

Autor*innen: Saraf, Isha; Modhave, Dattatray; Kushwah, Varun; Neshchadin, Dmytro; Gescheidt, Georg; Trausinger, Gert; Melchior, Philipp; Magnes, Christoph; Paudel, Amrit
Feasibility of rapidly assessing reactive impurities mediated excipient incompatibility using a new method: A case study of famotidine-PEG system
Health
2019

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Autor*innen: Carmona-Gutierrez, Didac; Zimmermann, Andreas; Kainz, Katharina; Pietrocola, Federico; Chen, Guo; Maglioni, Silvia; Schiavi, Alfonso; Nah, Jihoon; Mertel, Sara; Beuschel, Christine B.; Castoldi, Francesca; Sica, Valentina; Trausinger, Gert; Raml, Reingard; Sommer, Cornelia; Schroeder, Sabrina; Hofer, Sebastian J.; Bauer, Maria A.; Pendl, Tobias; Tadic, Jelena; Dammbrueck, Christopher; Hu, Zehan; Ruckenstuhl, Christoph; Eisenberg, Tobias; Durand, Sylvere; Bossut, Noélie; Aprahamian, Fanny; Abdellatif, Mahmoud; Sedej, Simon; Enot, David P.; Wolinski, Heimo; Dengjel, Jörn; Kepp, Oliver; Magnes, Christoph; Sinner, Frank M.; Pieber, Thomas R.; Sadoshima, Junichi; Ventura, Natascia; Sigrist, Stephan J.; Kroemer, Guido; Madeo, Frank
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
Health
2019

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

Autor*innen: Stekovic, Slaven; Hofer, Sebastian J.; Tripolt, Norbert; Aon, Miguel A.; Royer, Philipp; Pein, Lukas; Stadler, Julia T.; Pendl, Tobias; Prietl, Barbara; Url, Jasmin; Schroeder, Sabrina; Tadic, Jelena; Eisenberg, Tobias; Magnes, Christoph; Stumpe, Michael; Zuegner, Elmar; Bordag, Natalie; Riedl, Regina; Schmidt, Albrecht; Kolesnik, Ewald; Verheyen, Nicolas; Springer, Anna; Madl, Tobias; Sinner, Frank; de Cabo, Rafael; Kroemer, Guido; Obermayer-Pietsch, Barbara; Dengjel, Jöm; Sourij, Harald; Pieber, Thomas R.; Madeo, Frank
Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans
Health
2019

N ‐acetylaspartate availability is essential for juvenile survival on fat‐free diet and determines metabolic health

Autor*innen: Hofer, Dina C.; Zirkovits, Gabriel; Pelzmann, Helmut J.; Huber, Katharina; Pessentheiner, Ariane R.; Xia, Wenmin; Uno, Kyosuke; Miyazaki, Toh; Kon, Kanta; Tsuneki, Hiroshi; Pendl, Tobias; Zoughbi, Wael Al; Madreiter‐Sokolowski, Corina T.; Trausinger, Gert; Abdellatif, Mahmoud; Schoiswohl, Gabriele; Schreiber, Renate; Eisenberg, Tobias; Magnes, Christoph; Sedej, Simon; Eckhardt, Matthias; Sasahara, Masakiyo; Sasaoka, Toshiyasu; Nitta, Atsumi; Hoefler, Gerald; Graier, Wolfgang F.; Kratky, Dagmar; Auwerx, Johan; Bogner‐Strauss, Juliane G.
N ‐acetylaspartate availability is essential for juvenile survival on fat‐free diet and determines metabolic health
Health
2019

Targeting the H3K4 demethylase KDM5B reprograms the metabolome and phenotype of melanoma cells

Autor*innen: Vogel, Felix C.E.; Bordag, Natalie; Zügner, Elmar; Trajkovic-Arsic, Marija; Chauvistré, Heike; Shannan, Batool; Váraljai, Renáta; Horn, Susanne; Magnes, Christoph; Siveke, Jens; Schadendorf, Dirk; Roesch, Alexander
Targeting the H3K4 demethylase KDM5B reprograms the metabolome and phenotype of melanoma cells
Health
2019

N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes

Autor*innen: Huber, Katharina; Hofer, Dina C; Trefely, Sophie; Pelzmann, Helmut J.; Madreiter-Sokolowski, Corina; Duta-Mare, Madalina; Schlager, Stefanie; Trausinger, Gert; Stryeck, Sarah; Graier, Wolfgang F.; Kolb, Dagmar; Magnes, Christoph; Snyder, Nathaniel W.; Prokesch, Andreas; Kratky, Dagmar; Madl, Tobias; Wellen, Kathryn E.; Bogner-Strauss, Juliane G.
N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes
Health
2018

Impact of C-Peptide Status on the Response of Glucagon and Endogenous Glucose Production to Induced Hypoglycaemia in T1D.

Autor*innen: Zenz, Sabine; Mader, Julia K; Regittnig, Werner; Brunner, Martina; Korsatko, Stefan; Boulgaropoulos, Beate; Magnes, Christoph; Raml, Reingard; Narath, Sophie H.; Eller, Philipp; Augustin, Thomas; Pieber, Thomas R
Impact of C-Peptide Status on the Response of Glucagon and Endogenous Glucose Production to Induced Hypoglycaemia in T1D.
Health
2018

Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis

Autor*innen: Duta-Mare, Madalina; Sachdev, Vinay; Leopold, Christina; Kolb, Dagmar; Vujic, Nemanja; Korbelius, Melanie; Hofer, Dina C; Xia, Wenmin; Huber, Katharina; Auer, Martina; Gottschalk, Benjamin; Magnes, Christoph; Graier, Wolfgang F.; Prokesch, Andreas; Radovic, Branislav; Bogner-Strauss, Juliane G.; Kratky, Dagmar
Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis
Health
2018

Progesterone-associated arginine decline at luteal phase of menstrual cycle and associations with related amino acids and nuclear factor kB activation

Autor*innen: Faustmann, Gernot; Meinitzer, Andreas; Magnes, Christoph; Tiran, Beate; Obermayer-Pietsch, Barbara; Gruber, Hans-Jürgen; Ribalta, Josep; Rock, Edmond; Roob, Johannes M.; Winklhofer-Roob, Brigitte M.
Progesterone-associated arginine decline at luteal phase of menstrual cycle and associations with related amino acids and nuclear factor kB activation
Health
2018

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline

Autor*innen: Schwarz, Claudia; Stekovic, Slaven; Wirth, Miranka; Benson, Gloria; Royer, Philipp; Sigrist, Stephan J; Pieber, Thomas R; Dammbrueck, Christopher; Magnes, Christoph; Eisenberg, Tobias; Pendl, Tobias; Bohlken, Jens; Köe, Theresa; Madeo, Frank; Flöel, Agnes
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline
Health
2016

An Untargeted Metabolomics Approach to Characterize Short-Term and Long-Term Metabolic Changes after Bariatric Surgery

Autor*innen: Narath, Sophie H.; Mautner, Selma I.; Svehlikova, Eva; Schultes, Bernd; Pieber, Thomas R.; Sinner, Frank M.; Gander, Edgar; Libiseller, Gunnar; Schimek, Michael G.; Sourij, Harald; Magnes, Christoph
An Untargeted Metabolomics Approach to Characterize Short-Term and Long-Term Metabolic Changes after Bariatric Surgery
Health
2016

Matrix removal in state of the art sample preparation methods for serum by charged aerosol detection and metabolomics-based LC-MS

Autor*innen: Schimek, Denise; Francesconi, Kevin A.; Mautner, Anton; Libiseller, Gunnar; Raml, Reingard; Magnes, Christoph
Matrix removal in state of the art sample preparation methods for serum by charged aerosol detection and metabolomics-based LC-MS
Health
2016

Determination of (2)H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography - quadrupole-mass-spectrometry

Autor*innen: Eberl, A; Altendorfer‐Kroath, Thomas; Kollmann, D; Birngruber, Thomas; Sinner, F; Raml, R; Magnes, Christoph
Determination of (2)H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography - quadrupole-mass-spectrometry
Health
2016

N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes.

Autor*innen: Prokesch, Andreas; Pelzmann, H J; Pessentheiner, A R; Huber, K; Madreiter-Sokolowski, C T; Drougard, A; Schittmayer, M; Kolb, D; Magnes, Christoph; Trausinger, Gert; Graier, W F; Birner-Gruenberger, R; Pospisilik, J A; Bogner-Strauss, J G
N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes.
Health
2016

Cardioprotection and lifespan extension by the natural polyamine spermidine

Autor*innen: Eisenberg, Tobias; Abdellatif, Mahmoud; Schroeder, Sabrina; Primessnig, Uwe; Stekovic, Slaven; Pendl, Tobias; Harger, Alexandra; Schipke, Julia; Zimmermann, Andreas; Schmidt, Albrecht; Tong, Mingming; Ruckenstuhl, Christoph; Dammbrueck, Christopher; Gross, Angelina S; Herbst, Viktoria; Magnes, Christoph; Trausinger, Gert; Narath, Sophie; Meinitzer, Andreas; Hu, Zehan; Kirsch, Alexander; Eller, Kathrin; Carmona-Gutierrez, Didac; Büttner, Sabrina; Pietrocola, Federico; Knittelfelder, Oskar; Schrepfer, Emilie; Rockenfeller, Patrick; Simonini, Corinna; Rahn, Alexandros; Horsch, Marion; Moreth, Kristin; Beckers, Johannes; Fuchs, Helmut; Gailus-Durner, Valerie; Neff, Frauke; Janik, Dirk; Rathkolb, Birgit; Rozman, Jan; de Angelis, Martin Hrabe; Moustafa, Tarek; Haemmerle, Guenter; Mayr, Manuel; Willeit, Peter; von Frieling-Salewsky, Marion; Pieske, Burkert; Scorrano, Luca; Pieber, Thomas R; Pechlaner, Raimund; Willeit, Johann; Sigrist, Stephan J; Linke, Wolfgang A; Mühlfeld, Christian; Sadoshima, Junichi; Dengjel, Joern; Kiechl, Stefan; Kroemer, Guido; Sedej, Simon; Madeo, Frank
Cardioprotection and lifespan extension by the natural polyamine spermidine
Health
2016

Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication

Autor*innen: Fröhlich, Esther E.; Farzi, Aitak; Mayerhofer, Raphaela; Reichmann, Florian; Jačan, Angela; Wagner, Bernhard; Zinser, Erwin; Bordag, Natalie; Magnes, Christoph; Fröhlich, Eleonore Esther E.; Kashofer, Karl; Gorkiewicz, Gregor; Holzer, Peter
Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication
Health
2015

IPO: a tool for automated optimization of XCMS parameters

Autor*innen: Libiseller, Gunnar; Dvorzak, Michaela; Kleb, Ulrike; Gander, Edgar; Eisenberg, Tobias; Madeo, Frank; Neumann, Steffen; Trausinger, Gert; Sinner, Frank; Pieber, Thomas; Magnes, Christoph
IPO: a tool for automated optimization of XCMS parameters
Health
2015

Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin

Autor*innen: Braun, Ralf J.; Sommer, Cornelia; Leibiger, Christine; Gentier, Romina J.G.; Dumit, Verónica I.; Paduch, Katrin; Eisenberg, Tobias; Habernig, Lukas; Trausinger, Gert; Magnes, Christoph; Pieber, Thomas; Sinner, Frank; Dengjel, Jörn; van Leeuwen, Fred W.; Kroemer, Guido; Madeo, Frank
Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin
Health
2015

Identification of novel metabolic interactions controlling carbon flux from xylose to ethanol in natural and recombinant yeasts

Autor*innen: Trausinger, Gert; Gruber, Christoph; Krahulec, Stefan; Magnes, Christoph; Nidetzky, Bernd; Klimacek, Mario
Identification of novel metabolic interactions controlling carbon flux from xylose to ethanol in natural and recombinant yeasts
Health
2015

Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast

Autor*innen: Braun, Ralf J.; Sommer, Cornelia; Leibiger, Christine; Gentier, Romina; Dumit, Veronica; Paduch, Katrin; Eisenberg, Tobias; Habernig, Lukas; Trausinger, Gert; Magnes, Christoph; Pieber, Thomas R; Sinner, Frank M; Dengjel, Jörn; van Leeuwen, Fred; Kroemer, Guido; Madeo, Frank
Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast
Health
2013

Spermidine promotes mating and fertilization efficiency in model organisms

Autor*innen: Bauer, Maria Anna; Carmona-Gutiérrez, Didac; Ruckenstuhl, Christoph; Reisenbichler, Angela; Megalou, Evgenia V.; Eisenberg, Tobias; Magnes, Christoph; Jungwirth, Helmut; Sinner, Frank M; Pieber, Thomas R; Fröhlich, Kai Uwe; Kroemer, Guido; Tavernarakis, Nektarios; Madeo, Frank
Spermidine promotes mating and fertilization efficiency in model organisms
Health
2012

Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling

Autor*innen: Bodenlenz, Manfred; Höfferer, Christian; Magnes, Christoph; Schaller-Ammann, Roland; Schaupp, Lukas; Feichtner, Franz; Ratzer, Maria; Pickl, Karin; Sinner, Frank; Wutte, Andrea; Korsatko, Stefan; Köhler, Gerd; Legat, Franz J.; Benfeldt, Eva M.; Wright, Andrew M.; Neddermann, Daniel; Jung, Thomas; Pieber, Thomas R
Dermal PK/PD of a lipophilic topical drug in psoriatic patients by continuous intradermal membrane-free sampling
Health
2012

Remodeling of lipid droplets during lipolysis and growth in adipocytes

Autor*innen: Paar, Margret; Jüngst, Christian; Steiner, Noemi A.; Magnes, Christoph; Sinner, Frank; Kolb, Dagmar; Lass, Achim; Zimmermann, Robert; Zumbusch, Andreas; Kohlwein, Sepp D.; Wolinski, Heimo
Remodeling of lipid droplets during lipolysis and growth in adipocytes
Health
2012

Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury

Autor*innen: Moustafa, Tarek; Fickert, Peter; Magnes, Christoph; Guelly, Christian; Thueringer, Andrea; Frank, Sasa; Kratky, Dagmar; Sattler, Wolfgang; Reicher, Helga; Sinner, Frank; Gumhold, Judith; Silbert, Dagmar; Fauler, Günter; Höfler, Gerald; Lass, Achim; Zechner, Rudolf; Trauner, Michael
Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury
Health
2011

Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats

Autor*innen: Ardjomand-Woelkart, Karin; Kollroser, Manfred; Magnes, Christoph; Sinner, Frank; Frye, Reginald F; Derendorf, Hartmut; Bauer, Rudolf; Butterweck, Veronika
Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats
Health
2011

The propeptide of yeast cathepsin D inhibits programmed necrosis

Autor*innen: Carmona-Gutiérrez, D; Bauer, M A; Ring, J; Knauer, H; Eisenberg, T; Büttner, S; Ruckenstuhl, C; Reisenbichler, A; Magnes, C; Rechberger, G N; Birner-Gruenberger, R; Jungwirth, H; Fröhlich, K-U; Sinner, F; Kroemer, G; Madeo, F
The propeptide of yeast cathepsin D inhibits programmed necrosis
Health
2010

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase

Autor*innen: Chandak, Prakash G.; Radović, Branislav; Aflaki, Elma; Kolb, Dagmar; Buchebner, Marlene; Fröhlich, Eleonore; Magnes, Christoph; Sinner, Frank; Haemmerle, Guenter; Zechner, Rudolf; Tabas, Ira; Levak-Frank, Sanja; Kratky, Dagmar
Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase
Health
2009

Induction of autophagy by spermidine promotes longevity

Autor*innen: Eisenberg, Tobias; Knauer, Heide; Schauer, Alexandra; Büttner, Sabrina; Ruckenstuhl, Christoph; Carmona-Gutierrez, Didac; Ring, Julia; Schroeder, Sabrina; Magnes, Christoph; Antonacci, Lucia; Fussi, Heike; Deszcz, Luiza; Hartl, Regina; Schraml, Elisabeth; Criollo, Alfredo; Megalou, Evgenia; Weiskopf, Daniela; Laun, Peter; Heeren, Gino; Breitenbach, Michael; Grubeck-Loebenstein, Beatrix; Herker, Eva; Fahrenkrog, Birthe; Fröhlich, Kai-Uwe; Sinner, Frank; Tavernarakis, Nektarios; Minois, Nadege; Kroemer, Guido; Madeo, Frank
Induction of autophagy by spermidine promotes longevity
Health
2008

Insulin glulisine, insulin lispro and regular human insulin show comparable end-organ metabolic effects: an exploratory study

Autor*innen: Horvath, K; Bock, G; Regittnig, W; Bodenlenz, Manfred; Wutte, A; Plank, J; Magnes, Christoph; Sinner, F.; Fürst-Recktenwald, S.; Theobald, K; Pieber, Thomas R
Insulin glulisine, insulin lispro and regular human insulin show comparable end-organ metabolic effects: an exploratory study
Health
2008

Ring-opening metathesis polymerization-derived monolithic capillary columns for high-performance liquid chromatography. Downscaling and application in medical research

Autor*innen: Sinner, Frank M; Gatschelhofer, Christina; Mautner, Agnes; Magnes, Christoph; Buchmeiser, Michael R; Pieber, Thomas R
Ring-opening metathesis polymerization-derived monolithic capillary columns for high-performance liquid chromatography. Downscaling and application in medical research
Health
2008

Validated comprehensive analytical method for quantification of coenzyme A activated compounds in biological tissues by online solid-phase extraction LC/MS/MS.

Autor*innen: Magnes, Christoph; Suppan, Maria; Pieber, Thomas R; Moustafa, Tarek; Trauner, Michael; Haemmerle, Guenter; Sinner, Frank M
Validated comprehensive analytical method for quantification of coenzyme A activated compounds in biological tissues by online solid-phase extraction LC/MS/MS.
Health
2007

Proportional Dose-Response Relationship and Lower Within-Patient Variability of Insulin Detemir and NPH Insulin in Subjects With Type 1 Diabetes Mellitus

Autor*innen: Wutte, A; Plank, J; Bodenlenz, Manfred; Magnes, Christoph; Regittnig, W; Sinner, F.; Rønn, B.; Zdravkovic, M; Pieber, T.
Proportional Dose-Response Relationship and Lower Within-Patient Variability of Insulin Detemir and NPH Insulin in Subjects With Type 1 Diabetes Mellitus
Health
2007

Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion

Autor*innen: Pickl, Karin E.; Magnes, Christoph; Bodenlenz, Manfred; Pieber, Thomas R.; Sinner, Frank M.
Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion
Health
2005

A Double-Blind, Randomized, Dose-Response Study Investigating the Pharmacodynamic and Pharmacokinetic Properties of the Long-Acting Insulin Analog Detemir

Autor*innen: Plank, Johannes; Bodenlenz, Manfred; Sinner, Frank; Magnes, Christoph; Görzer, Evelyn; Regittnig, Werner; Endahl, Lars A.; Draeger, Eberhard; Zdravkovic, Milan; Pieber, Thomas R
A Double-Blind, Randomized, Dose-Response Study Investigating the Pharmacodynamic and Pharmacokinetic Properties of the Long-Acting Insulin Analog Detemir
Health
2005

LC/MS/MS Method for Quantitative Determination of Long-Chain Fatty Acyl-CoAs

Autor*innen: Magnes, Christoph; Sinner, Frank M; Regittnig, Werner; Pieber, Thomas R
LC/MS/MS Method for Quantitative Determination of Long-Chain Fatty Acyl-CoAs
Health
2005

Evaluation of ring-opening metathesis polymerization (ROMP)-derived monolithic capillary high performance liquid chromatography columns

Autor*innen: Gatschelhofer, Christina; Magnes, Christoph; Pieber, Thomas R; Buchmeiser, Michael R; Sinner, Frank M
Evaluation of ring-opening metathesis polymerization (ROMP)-derived monolithic capillary high performance liquid chromatography columns
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