Open flow microperfusion

OFM is a probe-based method that is used to evaluate the pharmacokinetics and pharmacodynamics of drugs directly in skin, adipose and brain tissue. The use of the OFM probes allows small amounts of interstitial fluid (ISF) to be collected from target tissues for analysis. OFM is particularly suitable for the analysis of large, lipophilic substances.

We use OFM in clinical and preclinical studies.

OFM in Skin and Adipose Tissue

dOFM and aOFM probes

  • dOFM - dermal OFM probes
  • aOFM - adipose tissue OFM probes
  • Meets CE mark requirements
  • Minimally invasive
  • Membrane-free
  • 0.36 mm diameter
  • 15 mm exchange area in the tissue
  • Luer-lock fittings
  • Numerous accessories
  • For use in preclinical and clinical studies
  • Applications: skin and adipose tissue
  • Patented
OFM in the Brain

cOFM probe

  • cOFM - cerebral OFM probe
  • Only for preclinical use
  • cOFM probes for use in mice and rats available
  • Fluorinated ethylene propylene (FEP) material: 0.8 mm diameter, 5 mm length
  • High-precision stereotactic implantation
  • Used in combination with a removable healing dummy
  • Allows for tissue regeneration after implantation
  • No tissue trauma
  • No tissue in-growth into the guide cannula
  • Patent pending
OFM Pumps

OFM Pumps

  • Operate up to 3 aOFM or dOFM probes
  • Portable
  • Perfusion rate: 0.1-10 µl/min
  • Push-pull (recirculation) operation mode available (independent rate settings for push and pull)
  • For use in preclinical and clinical studies
  • Patent pending