Chronic Wounds

In a society that is progressively, getting older, chronic wounds are a serious problem with increasing importance. More efficient diagnostic procedures as well as innovative therapy approaches are of great necessity from a health as well as socio-political point of view.

The development of chronic wounds is favored by various factors, such as poor blood circulation, diabetes mellitus, and high blood pressure. For the development of more efficient diagnostic procedures as well as for the testing of new therapeutic approaches, preclinical models are required that reflect the clinical situation as well as possible.

Development and optimization of preclinical models for the formation of chronic wounds, in consideration of:

  • hyperinflammation
  • infections
  • ischemia
  • oxidative stress
  • age
  • diabetes mellitus

Basic mechanisms that lead to chronic wounds. Photo credit: JOANNEUM RESEARCH/Hofmann