Hypertrophic scar

Scarring is considered the body's physiological response to deeper injuries to the skin. Ideally, scars develop flat and barely visible. However, excessive scarring - so-called hypertrophic scars - can occur, which are often not only an aesthetic problem for the person concerned. Hypertrophic scars are usually bulging, reddened, raised from the surrounding skin level and patients often suffer of severe itching and pain.

This excessive scarring is, among other factors, caused by an overproduction of collagen and connective tissue fibers. The pathophysiology of hypertrophic scars has not yet been fully clarified - which in turn explains the lack of effective and evidence-based treatment concepts. Therefore, the establishment of a representative model is urgently imperative- on the one hand to better understand the development processes of hypertrophic scars, and on the other hand to further develop and optimize the existing therapy options.

This is where we come into play and develop preclinical models for hypertrophic scars, research the underlying pathophysiology and thus offer the opportunity to optimize existing therapies and to develop new therapeutic approaches using those novel models.

  • Understanding the formation processes of hypertrophic scars
  • Testing and developing innovative therapeutic approaches


  • Nischwitz SP, Rauch K, Luze H, Hofmann E, Draschl A, Kotzbeck P, Kamolz LP. Evidence-based therapy in hypertrophic scars: An update of a systematic review. Wound Repair Regen. 2020 Sep;28(5):656-665. doi: 10.1111/wrr.12839. Epub 2020 Jun 15.